RIFAMYCIN ANALOGS AND USES THEREOF

Title:

RIFAMYCIN ANALOGS AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO2005020894

Kind Code:

A3

Abstract:

The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivated at various positions of the benzene ring, including 3'-hydroxy analogs, 4'-and/or 6'halo and/or alkoxy analogs, and various 5' substituents that incorporate a cyclic amine moiety.

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Inventors:

DUZER JOHN H VAN (US)
MICHAELIS ARTHUR F (US)
RAKER JOSEPH (US)
STAFFORD DOUGLAS G (US)
GEISS WILLIAM B (US)

Application Number:

PCT/US2004/026006

Publication Date:

July 27, 2006

Filing Date:

August 11, 2004

Export Citation:

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Assignee:

ACTIVBIOTICS INC (US)
DUZER JOHN H VAN (US)
MICHAELIS ARTHUR F (US)
RAKER JOSEPH (US)
STAFFORD DOUGLAS G (US)
GEISS WILLIAM B (US)

International Classes:

C07D498/18; A61K31/502; A61K31/538; A61K31/5415; A61P31/04; A61P31/12; A61P33/02; C07D491/18; C07D513/18; C07D519/00

Domestic Patent References:

WO1997009047A1

1997-03-13

Other References: