RIP1 MODULATORS, PREPARATIONS, AND USES THEREOF

Title:

RIP1 MODULATORS, PREPARATIONS, AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/160638

Kind Code:

A1

Abstract:

This disclosure provides compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating various diseases and conditions, e. g., including those mediated by receptor-interacting protein 1 (RIP1) signaling.

Inventors:

SU YANING (CN)
RUAN HANYING (CN)
XU YANPING (CN)
JIANG YIMIN (CN)
SUN ZHEN (CN)
HAO JUNLIANG (CN)
LI BO (CN)
ZHANG ZHIYUAN (CN)

Application Number:

PCT/CN2023/078015

Publication Date:

August 31, 2023

Filing Date:

February 24, 2023

Export Citation:

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Assignee:

SIRONAX LTD (GB)
SU YANING (CN)

International Classes:

C07D417/12; A61K31/495; A61K31/541; A61P25/00; A61P29/00; A61P31/00; A61P37/00; A61P37/08; C07D417/14; C07D487/04

Domestic Patent References:

WO2021234450A1

2021-11-25

Foreign References:

CN1993339A	2007-07-04
CN101828111A	2010-09-08
CN101321529A	2008-12-10
JP2007231005A	2007-09-13
EP1834953A1	2007-09-19
US4846875A	1989-07-11
CN101723909A	2010-06-09
CN108191835A	2018-06-22
US20210371430A1	2021-12-02

Other References:

NAKATANI MAMORU, KIYOSHI YAMASHITA, SENJI TOSA: "Syntheses of 2-pyrazolin-5-ones having nitrogen-containing cyclic imido substituent on the 3-position", YAKUGAKU ZASSHI, vol. 103, no. 9, 1 January 1983 (1983-01-01), pages 922 - 928, XP093088644, DOI: 10.1248/yakushi1947.103.9_922
DATABASE REGISTRY ANONYMOUS : "- 2(1H)-Pyrimidinone, tetrahydro-1-[(3-methylphenyl)methyl]-3-[4-[(4-phenyl1-piperazinyl)carbonyl]phenyl]- (CA INDEX NAME)", XP093088643, retrieved from STN

Attorney, Agent or Firm:

CHINA PATENT AGENT (H.K.) LTD. (CN)

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