Title:
RNA APTAMER SPECIFICALLY BINDING TO LXRα PROTEIN AND USE OF RNA APTAMER
Document Type and Number:
WIPO Patent Application WO/2021/080301
Kind Code:
A1
Abstract:
The present invention relates to an RNA aptamer that specifically binds to LXRα protein and use of the RNA aptamer. Specifically, the RNA aptamer according to the present invention specifically and strongly binds to LXRα protein, inhibits adipose differentiation, and inhibits the expression of adipose differentiation-associated genes and proteins, and thus can be effectively used for LXRα protein detection and fat diagnosis.
Inventors:
KIM YANG HOON (KR)
CHO HEE YOUNG (KR)
SHIN WOO RI (KR)
CHO HEE YOUNG (KR)
SHIN WOO RI (KR)
Application Number:
PCT/KR2020/014375
Publication Date:
April 29, 2021
Filing Date:
October 21, 2020
Export Citation:
Assignee:
NAT UNIV CHUNGBUK IND ACAD COOP FOUND (KR)
International Classes:
C12N15/115; A23L33/10; A61K31/7088; A61P3/04; G01N33/68
Foreign References:
| US20160310454A1 | 2016-10-27 | |||
| US20050080111A1 | 2005-04-14 |
Other References:
LU PENG , XING-SHAN ZHAO, DACHENG PENG: "Anti-obesity Effect of a Novel Potent Synthetic Steroidal Liver X Receptor α (LXRα)-selective Agonist in Male ob/ob C57BL/6 Mice", INTERNATIONAL JOURNAL OF PHARMACOLOGY, vol. 13, no. 6, 1 January 2017 (2017-01-01), pages 636 - 642, XP055805837, ISSN: 1811-7775, DOI: 10.3923/ijp.2017.636.642
SURUGIU-WARNMARK, I. ; WARNMARK, A. ; TORESSON, G. ; GUSTAFSSON, J.A. ; BULOW, L.: "Selection of DNA aptamers against rat liver X receptors", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 332, no. 2, 1 July 2005 (2005-07-01), pages 512 - 517, XP027230028, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2005.04.147
LAURENCIKIENE J, RYDÉN M: "Liver X receptors and fat cell metabolism", INTERNATIONAL JOURNAL OF OBESITY, vol. 36, no. 12, 28 February 2012 (2012-02-28), pages 1494 - 1502, XP055805842, DOI: 10.1038/ijo.2012.21
SURUGIU-WARNMARK, I. ; WARNMARK, A. ; TORESSON, G. ; GUSTAFSSON, J.A. ; BULOW, L.: "Selection of DNA aptamers against rat liver X receptors", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 332, no. 2, 1 July 2005 (2005-07-01), pages 512 - 517, XP027230028, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2005.04.147
LAURENCIKIENE J, RYDÉN M: "Liver X receptors and fat cell metabolism", INTERNATIONAL JOURNAL OF OBESITY, vol. 36, no. 12, 28 February 2012 (2012-02-28), pages 1494 - 1502, XP055805842, DOI: 10.1038/ijo.2012.21
Attorney, Agent or Firm:
WETHEPEOPLE IP & LAW FIRM (KR)
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