Title:
RNA-DIRECTED PACKAGING OF ENZYMES WITHIN PROTEIN PARTICLES
Document Type and Number:
WIPO Patent Application WO/2012/061445
Kind Code:
A3
Abstract:
Protein nanoparticles encapsulate cargo proteins within an enclosure containing a protected chemical milieu. Encapsulation within such protected chemicai milieu enhances the employabiiity and performance of cargo proteins, particularly cargo enzymes, particularly within otherwise hostile chemical environments. Protein nanoparticles are assembled using shell proteins, such as viral coat proteins like Qβ, in the presence of a bifunctional polynucleotide and the selected cargo protein. The bifunctional polynucleotide includes two aptameric activities that assist the disposition and retention of cargo proteins within the protein nanoparticle.
Inventors:
FINN M G (US)
BROWN STEVEN (US)
FIEDLER JASON (US)
BROWN STEVEN (US)
FIEDLER JASON (US)
Application Number:
PCT/US2011/058859
Publication Date:
June 21, 2012
Filing Date:
November 01, 2011
Export Citation:
Assignee:
QAPSULE TECHNOLOGIES INC (US)
FINN M G (US)
BROWN STEVEN (US)
FIEDLER JASON (US)
FINN M G (US)
BROWN STEVEN (US)
FIEDLER JASON (US)
International Classes:
A01N25/28; A01N25/26; A61K9/16; A61K9/50; A61K9/64
Foreign References:
| US20090041671A1 | 2009-02-12 | |||
| US20070225213A1 | 2007-09-27 | |||
| US20100167981A1 | 2010-07-01 |
Attorney, Agent or Firm:
LEWIS, Donald, G. (Kohn & Fitzwilliam LLP10935 Vista Sorrento Parkway, Suite 37, San Diego CA, US)
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