Title:
RNA INTERACTOME CAPTURING PROTOCOL AND ANTIVIRAL COMPOSITION DISCOVERED USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/092995
Kind Code:
A3
Abstract:
The present invention relates to an RNA interactome capturing protocol and an antiviral composition discovered using same. When used, the antiviral composition and pharmaceutical composition of the present invention can effectively inhibit viral infection and suppress viral proliferation in vivo after viral infection.
Inventors:
KIM V NARRY (KR)
LEE SUNGYUL (KR)
LEE YOUNG-SUK (KR)
LEE SUNGYUL (KR)
LEE YOUNG-SUK (KR)
Application Number:
PCT/KR2021/015742
Publication Date:
June 23, 2022
Filing Date:
November 02, 2021
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
INST BASIC SCIENCE (KR)
INST BASIC SCIENCE (KR)
International Classes:
C12Q1/70; C12Q1/6825
Foreign References:
| KR20130126243A | 2013-11-20 |
Other References:
FLYNN RYAN A., BELK JULIA A., QI YANYAN, YASUMOTO YUKI, SCHMITZ CAMERON O., MUMBACH MAXWELL R., LIMAYE ADITI, WEI JIN, ALFAJARO MI: "Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection", BIORXIV, 6 October 2020 (2020-10-06), XP055942840, Retrieved from the Internet DOI: 10.1101/2020.10.06.327445
MCHUGH COLLEEN A., GUTTMAN MITCHELL: "RAP-MS: a method to identify proteins that interact directly with a specific RNA molecule in cells", RNA DETECTION, 1 January 2018 (2018-01-01), pages 473 - 488, XP009537610, ISBN: 978-1-4939-7212-8, DOI: 10.1007/978-1-4939-7213-5_31
SRIVASTAVA RAJNEESH, DAULATABAD SWAPNA VIDHUR, SRIVASTAVA MANSI, JANGA SARATH CHANDRA: "Role of SARS-CoV-2 in Altering the RNA-Binding Protein and miRNA-Directed Post-Transcriptional Regulatory Networks in Humans", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 19, 25 September 2020 (2020-09-25), pages 7090, XP055942844, DOI: 10.3390/ijms21197090
BIRGIT ROGELL, FISCHER BERND, RETTEL MANDY, KRIJGSVELD JEROEN, CASTELLO ALFREDO, HENTZE MATTHIAS W: "Specific RNP capture with antisense LNA/DNA mixmers", RNA, vol. 23, no. 8, 1 August 2017 (2017-08-01), pages 1290 - 1302, XP055429152, DOI: 10.1261/rna
LEE SUNGYUL; LEE YOUNG-SUK; CHOI YEON; SON AHYEON; PARK YOUNGRAN; LEE KYUNG-MIN; KIM JEESOO; KIM JONG-SEO; KIM V. NARRY: "The SARS-CoV-2 RNA interactome", MOLECULAR CELL, ELSEVIER, AMSTERDAM, NL, vol. 81, no. 13, 27 April 2021 (2021-04-27), AMSTERDAM, NL, pages 2838, XP086691852, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2021.04.022
MCHUGH COLLEEN A., GUTTMAN MITCHELL: "RAP-MS: a method to identify proteins that interact directly with a specific RNA molecule in cells", RNA DETECTION, 1 January 2018 (2018-01-01), pages 473 - 488, XP009537610, ISBN: 978-1-4939-7212-8, DOI: 10.1007/978-1-4939-7213-5_31
SRIVASTAVA RAJNEESH, DAULATABAD SWAPNA VIDHUR, SRIVASTAVA MANSI, JANGA SARATH CHANDRA: "Role of SARS-CoV-2 in Altering the RNA-Binding Protein and miRNA-Directed Post-Transcriptional Regulatory Networks in Humans", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 19, 25 September 2020 (2020-09-25), pages 7090, XP055942844, DOI: 10.3390/ijms21197090
BIRGIT ROGELL, FISCHER BERND, RETTEL MANDY, KRIJGSVELD JEROEN, CASTELLO ALFREDO, HENTZE MATTHIAS W: "Specific RNP capture with antisense LNA/DNA mixmers", RNA, vol. 23, no. 8, 1 August 2017 (2017-08-01), pages 1290 - 1302, XP055429152, DOI: 10.1261/rna
LEE SUNGYUL; LEE YOUNG-SUK; CHOI YEON; SON AHYEON; PARK YOUNGRAN; LEE KYUNG-MIN; KIM JEESOO; KIM JONG-SEO; KIM V. NARRY: "The SARS-CoV-2 RNA interactome", MOLECULAR CELL, ELSEVIER, AMSTERDAM, NL, vol. 81, no. 13, 27 April 2021 (2021-04-27), AMSTERDAM, NL, pages 2838, XP086691852, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2021.04.022
Attorney, Agent or Firm:
KONG, Byung Wook (KR)
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