Title:
RNAI REAGENT AND COMPOSITION FOR INHIBITING SURF4 GENE EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2022/100706
Kind Code:
A1
Abstract:
Provided are a short antisense oligonucleotide for inhibiting SURF4 expression, and an RNAi reagent and a composition thereof. The short antisense oligonucleotide, the RNAi reagent or the composition can reduce blood lipids in a subject, and can be used to treat or prevent diseases related to dyslipidemia.
Inventors:
CHEN XIAOWEI (CN)
WANG XIAO (CN)
XU BOLIN (CN)
FANG HUAN (CN)
WANG XIAO (CN)
XU BOLIN (CN)
FANG HUAN (CN)
Application Number:
PCT/CN2021/130426
Publication Date:
May 19, 2022
Filing Date:
November 12, 2021
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
C12N15/113
Foreign References:
| CN109957565A | 2019-07-02 | |||
| CN111107853A | 2020-05-05 | |||
| CN110882378A | 2020-03-17 |
Other References:
ZHENG XIANGZHEN: "Studies on the Mechanism by Which Surf4 Regulates Pcsk9 Secretion", MASTER THESIS, TIANJIN POLYTECHNIC UNIVERSITY, CN, no. 6, 15 June 2020 (2020-06-15), CN , XP055929566, ISSN: 1674-0246
SAEGUSA KEIKO, SATO MIYUKI, MOROOKA NOBUKATSU, HARA TAICHI, SATO KEN: "SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization", THE JOURNAL OF CELL BIOLOGY, THE ROCKEFELLER UNIVERSITY PRESS, US, vol. 217, no. 6, 4 June 2018 (2018-06-04), US , pages 2073 - 2085, XP055929605, ISSN: 0021-9525, DOI: 10.1083/jcb.201708115
SAEGUSA KEIKO, SATO MIYUKI, MOROOKA NOBUKATSU, HARA TAICHI, SATO KEN: "SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization", THE JOURNAL OF CELL BIOLOGY, THE ROCKEFELLER UNIVERSITY PRESS, US, vol. 217, no. 6, 4 June 2018 (2018-06-04), US , pages 2073 - 2085, XP055929605, ISSN: 0021-9525, DOI: 10.1083/jcb.201708115
Attorney, Agent or Firm:
IPFAITH PARTNERS (CN)
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