ROCK INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREFOR

WIPO Patent Application WO/2020/211751

A1

The compound shown in formula I, and racemates, stereoisomers, tautomers, isotopic markers, nitrogen oxides, solvates, polymorphs, metabolites, esters, pharmaceutically acceptable salts, or prodrugs thereof. The compound shown in formula I has excellent ROCK inhibitory activity. In addition, the compound shown in formula I has good safety and metabolic stability. Furthermore, the compound shown in formula I has a low risk of cardiotoxicity. Finally, the compound shown in formula I has a simple preparation method and is easy to purify, and therefore has good application prospects. (I)

LIU JUNHUA (CN)
CHEN YONGKAI (CN)
GUO XIAODAN (CN)
ZHANG YIHAN (CN)
ZENG XIAN (CN)
QIAN LINA (CN)
WANG CHAODONG (CN)

PCT/CN2020/084710

October 22, 2020

April 14, 2020

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WUHAN LL SCIENCE AND TECH DEVELOPMENT CO LTD (CN)
WUHAN QR PHARMACEUTICALS CO LTD (CN)

C07D487/04; A61K31/53; A61K31/5377; A61P1/16; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P15/10; A61P19/10; A61P25/00; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P37/02

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