Title:
ROCK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/012409
Kind Code:
A1
Abstract:
A ROCK inhibitor represented by formula (I), and a preparation method therefor and a use thereof. The ROCK inhibitor has excellent ROCK inhibition activity, particularly shows good selective inhibition on ROCK2 kinase, has good safety and metabolic stability, and is high in bioavailability. The preparation method for the ROCK inhibitor is simple, and the ROCK inhibitor is easy to purify, and therefore has a good application prospect.
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Inventors:
LI JINPING (CN)
ZENG JING (CN)
GUO XIAODAN (CN)
PENG WEI (CN)
LOU JUN (CN)
LIU LI (CN)
CHEN XIAOYA (CN)
ZHANG YIHAN (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
WU WEI (CN)
YUAN YI (CN)
ZENG JING (CN)
GUO XIAODAN (CN)
PENG WEI (CN)
LOU JUN (CN)
LIU LI (CN)
CHEN XIAOYA (CN)
ZHANG YIHAN (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
WU WEI (CN)
YUAN YI (CN)
Application Number:
PCT/CN2021/105263
Publication Date:
January 20, 2022
Filing Date:
July 08, 2021
Export Citation:
Assignee:
WUHAN LL SCIENCE AND TECH DEVELOPMENT CO LTD (CN)
International Classes:
C07D471/06; A61K31/395; A61K31/506; A61P3/08; A61P9/00; A61P35/00; C07D293/10; C07D401/14; C07D487/02
Domestic Patent References:
| WO2019000682A1 | 2019-01-03 | |||
| WO2019000683A1 | 2019-01-03 | |||
| WO2020094111A1 | 2020-05-14 | |||
| WO2015157556A1 | 2015-10-15 | |||
| WO2010104851A1 | 2010-09-16 |
Foreign References:
| CN202010676711A | 2020-07-14 | |||
| CN202110040185A | 2021-01-11 |
Other References:
See also references of EP 4155308A4
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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