Title:
ROCK INHIBITORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/226965
Kind Code:
A1
Abstract:
Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, that are useful as ROCK inhibitors. Also disclosed are pharmaceutical compositions comprising a compound of Formula (I), and methods of using such compounds or compositions to treat ROCK-related disorder (e.g., glaucoma).
Inventors:
WANG RUMIN (CN)
QI CHANGHE (CN)
TSUI HONCHUNG (CN)
ZENG QINGBEI (CN)
YANG ZHENFAN (CN)
ZHANG XIAOLIN (CN)
QI CHANGHE (CN)
TSUI HONCHUNG (CN)
ZENG QINGBEI (CN)
YANG ZHENFAN (CN)
ZHANG XIAOLIN (CN)
Application Number:
PCT/CN2023/095713
Publication Date:
November 30, 2023
Filing Date:
May 23, 2023
Export Citation:
Assignee:
DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/04; A61K31/415; A61K31/437; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P19/10; A61P25/00; A61P27/06; C07D401/14; C07D471/04
Domestic Patent References:
| WO2021093795A1 | 2021-05-20 |
Foreign References:
| CN106817899A | 2017-06-09 | |||
| CN105579452A | 2016-05-11 | |||
| CN107074818A | 2017-08-18 |
Other References:
CHOWDHURY S.: "Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)", BIOORG. MED. CHEM. LETT., vol. 21, 24 September 2011 (2011-09-24), XP028334849, DOI: 10.1016/j.bmcl.2011.09.083
SARWAT CHOWDHURY; E. HAMPTON SESSIONS; JENNIFER R. POCAS; WAYNE GRANT; THOMAS SCHRTER; LI LIN; CLAUDIA RUIZ; MICHAEL D. CAMERON; S: "Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 21, no. 23, 20 September 2011 (2011-09-20), Amsterdam NL , pages 7107 - 7112, XP028334849, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2011.09.083
SARWAT CHOWDHURY; E. HAMPTON SESSIONS; JENNIFER R. POCAS; WAYNE GRANT; THOMAS SCHRTER; LI LIN; CLAUDIA RUIZ; MICHAEL D. CAMERON; S: "Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 21, no. 23, 20 September 2011 (2011-09-20), Amsterdam NL , pages 7107 - 7112, XP028334849, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2011.09.083
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
Download PDF:
Previous Patent: HETEROCYCLIC DERIVATIVES, COMPOSITIONS AND USES THEREOF
Next Patent: FLUID EJECTION APPARATUS AND FLUID EJECTION DEVICE
Next Patent: FLUID EJECTION APPARATUS AND FLUID EJECTION DEVICE