Title:
ROMO1-DERIVED ANTIMICROBIAL PEPTIDES INCLUDING LYSINE SUBSTITUTION AND VARIANTS THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/256392
Kind Code:
A1
Abstract:
The present invention relates to Romo1 protein-derived antimicrobial peptides and, in particular, provides various peptides that each have an amino acid sequence of the α-helix 2 region of Romo1 protein and are confirmed for antimicrobial activity against Gram-positive, Gram-negative, and multidrug-resistant bacteria, and an antimicrobial composition comprising the peptides. The Romo1-derived peptides of the present invention and variants thereof are superior to existing antibiotics and antibiotic peptides in terms of antibiotic capability against various types of bacteria and multidrug-resistant bacteria, and in particular, have antimicrobial activity against various bacteria in blood vessels and as such, are novel antibiotics that can be provided as substances for the prevention or treatment of a wide range of bacterial infectious diseases. Thus, compositions comprising the antimicrobial peptides of the present invention are expected to find applications with the aim of preventing or treating infectious diseases in various fields, such as for use as drugs, quasi-drugs, food and feed additives, and agricultural and cosmetic additives.
Inventors:
YOO YOUNG DO (KR)
LEE HYE RA (KR)
LEE HYE RA (KR)
Application Number:
PCT/KR2020/007816
Publication Date:
December 24, 2020
Filing Date:
June 17, 2020
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07K7/08; A01N33/08; A23K20/147; A23K20/195; A23L3/3463; A23L33/18; A61K8/64; A61K38/00; A61P31/04; A61Q17/00
Foreign References:
| KR20180123866A | 2018-11-20 | |||
| KR20170032689A | 2017-03-23 | |||
| KR20180091920A | 2018-08-16 |
Other References:
GI YOUNG LEE, DEOK-GYUN YOU, HYE-RA LEE, SUN WOOK HWANG, C. JUSTIN LEE, YOUNG DO YOO: "Romo1 is a mitochondrial nonselective cation channel with viroporin-like characteristics", THE JOURNAL OF CELL BIOLOGY, THE ROCKEFELLER UNIVERSITY PRESS, US, vol. 217, no. 6, 4 June 2018 (2018-06-04), US, pages 2059 - 2071, XP055767114, ISSN: 0021-9525, DOI: 10.1083/jcb.201709001
NCBI. GenBank Accession No. KFW95923.1. Reactive oxygen species modulator 1, partial [Phalacrocorax carbo]. 08 September 2014. See entire document.
SE JIN SONG, JON G SANDERS, FRÉDÉRIC DELSUC, JESSICA METCALF, KATHERINE AMATO, MICHAEL W TAYLOR, FLORENT MAZEL, HOLLY L LUTZ, KEVI: "Comparative Analyses of Vertebrate Gut Microbiomes Reveal Convergence between Birds and Bats", MBIO, AMERICAN SOCIETY FOR MICROBIOLOGY, 25 February 2020 (2020-02-25), XP055767119, DOI: 10.1128/mBio
WHO, GLOBAL PRIORITY LIST OF ANTIBIOTIC-RESISTANT BACTERIA TO GUIDE RESEARCH, DISCOVERY, AND DEVELOPMENT OF NEW ANTIBIOTICS, 27 February 2017 (2017-02-27)
LEE ET AL., J. CELL BIOL., vol. 217, 2018, pages 2059 - 2071
See also references of EP 3985013A4
NCBI. GenBank Accession No. KFW95923.1. Reactive oxygen species modulator 1, partial [Phalacrocorax carbo]. 08 September 2014. See entire document.
SE JIN SONG, JON G SANDERS, FRÉDÉRIC DELSUC, JESSICA METCALF, KATHERINE AMATO, MICHAEL W TAYLOR, FLORENT MAZEL, HOLLY L LUTZ, KEVI: "Comparative Analyses of Vertebrate Gut Microbiomes Reveal Convergence between Birds and Bats", MBIO, AMERICAN SOCIETY FOR MICROBIOLOGY, 25 February 2020 (2020-02-25), XP055767119, DOI: 10.1128/mBio
WHO, GLOBAL PRIORITY LIST OF ANTIBIOTIC-RESISTANT BACTERIA TO GUIDE RESEARCH, DISCOVERY, AND DEVELOPMENT OF NEW ANTIBIOTICS, 27 February 2017 (2017-02-27)
LEE ET AL., J. CELL BIOL., vol. 217, 2018, pages 2059 - 2071
See also references of EP 3985013A4
Attorney, Agent or Firm:
PCR INTELLECTUAL PROPERTY LAW FIRM (KR)
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