Title:
S-CONFIGURATION-CONTAINING AMINO BENZAMIDE PYRIDAZINONE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/174803
Kind Code:
A1
Abstract:
The present invention relates to an S-configuration-containing amino benzamide pyridazinone compound, a preparation method therefor, and a pharmaceutical composition and application thereof. Specifically, the present invention relates to a compound represented by the following general formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition and application thereof. The S-configuration compound of the present application has very strong binding activity on class I histone deacetylase (HDAC1), and shows inhibitory activity on in-vitro proliferation of various tumor cells.
Inventors:
HU YOUHONG (CN)
GENG MEIYU (CN)
LI DAQIANG (CN)
SHEN AIJUN (CN)
ZHANG ZHUO (CN)
LI YALEI (CN)
YANG HUAJIE (CN)
LIU HONGCHUN (CN)
ZHONG HANYUE (CN)
DING JIAN (CN)
GENG MEIYU (CN)
LI DAQIANG (CN)
SHEN AIJUN (CN)
ZHANG ZHUO (CN)
LI YALEI (CN)
YANG HUAJIE (CN)
LIU HONGCHUN (CN)
ZHONG HANYUE (CN)
DING JIAN (CN)
Application Number:
PCT/CN2022/076727
Publication Date:
August 25, 2022
Filing Date:
February 18, 2022
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D237/14; A61K31/50; A61K31/501; A61P3/10; A61P25/28; A61P35/00; C07D237/22; C07D403/04; C07D413/04; C07D413/10; C07D417/04
Domestic Patent References:
| WO2012030990A1 | 2012-03-08 |
Foreign References:
| CN109280032A | 2019-01-29 | |||
| CN102666500A | 2012-09-12 | |||
| CA2900431A1 | 2014-08-14 | |||
| CN109280032A | 2019-01-29 |
Other References:
NAT. REV. DRUG. DISCOV, vol. 13, no. 9, 2014, pages 673 - 691
ADV. CANCER. RES., vol. 138, 2018, pages 183 - 211
See also references of EP 4296266A4
ADV. CANCER. RES., vol. 138, 2018, pages 183 - 211
See also references of EP 4296266A4
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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