Title:
S-(LOWER FATTY ACID)-SUBSTITUTED GLUTATHIONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1991/016337
Kind Code:
A1
Abstract:
An S-(lower fatty acid)-substituted glutathione derivative of general formula (I), salts thereof, and production thereof, wherein R1 represents hydrogen, R3 represents hydrogen or optionally substituted lower alkyl, R4 represents optionally substituted lower alkoxy or optionally substituted amino, and n is 0 or 1, provided that when n is 1, R2 represents hydrogen, optionally substituted lower alkyl, or optionally substituted phenyl. These compounds can be advantageously used for treating hepatic disorders, because they have an excellent activity of inhibiting these disorders.
Inventors:
OHMORI SHINJI (JP)
OGATA KAZUMI (JP)
SAKAUE TAKAHIRO (JP)
OGATA KAZUMI (JP)
SAKAUE TAKAHIRO (JP)
Application Number:
PCT/JP1991/000570
Publication Date:
October 31, 1991
Filing Date:
April 25, 1991
Export Citation:
Assignee:
SENJU PHARMA CO (JP)
International Classes:
C07K5/02; C07K5/093; A61K38/00; A61K38/06; (IPC1-7): A61K37/02; C07K1/02; C07K5/02
Foreign References:
| JPS61249958A | 1986-11-07 | |||
| JPS60237963A | 1985-11-26 | |||
| JPS60123497A | 1985-07-02 | |||
| JPH02500841A | 1990-03-22 |
Other References:
Anal. Biochem., Vol. 183, No. 1 (1989) LEESA J. DETERDING et al. "Fast atom bombardment and tandem mass spectrometry for structure determination of cystein, N-acetylcystein, and glutathione adducts of xenobiotics" pp. 94-107.
Br. J. Ind. Med., Vol. 32, No. 1 (1975) PHILIPPA M. EDWARDS "Neurotoxicity of acrylamide and its analogs and effects of these analogs and other agents on acrylamide neuropathy" pp. 31-38.
Biochem. J., Vol. 125, No. 1 (1971) T. W. SPEIR et al. "Conjugation of glutathione with unsaturated acyl thiol esters and the metabolic formation of S-carboxyalkylcysteins" pp. 267-273.
CHEMICAL ABSTRACTS, Vol. 56, No. 1, January 8, 1962 (08. 01. 62), (Columbus, Ohio, U.S.A.) WALTER G. TOEKELT, "New r-L-glutamyl peptides in onion (Allium cepa). III", Abstract No. 716f, Suomen Kemistilehti 34B, 53-54 (1961).
Br. J. Ind. Med., Vol. 32, No. 1 (1975) PHILIPPA M. EDWARDS "Neurotoxicity of acrylamide and its analogs and effects of these analogs and other agents on acrylamide neuropathy" pp. 31-38.
Biochem. J., Vol. 125, No. 1 (1971) T. W. SPEIR et al. "Conjugation of glutathione with unsaturated acyl thiol esters and the metabolic formation of S-carboxyalkylcysteins" pp. 267-273.
CHEMICAL ABSTRACTS, Vol. 56, No. 1, January 8, 1962 (08. 01. 62), (Columbus, Ohio, U.S.A.) WALTER G. TOEKELT, "New r-L-glutamyl peptides in onion (Allium cepa). III", Abstract No. 716f, Suomen Kemistilehti 34B, 53-54 (1961).
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