Title:
S-(-)-NICOTINE(-)-DIBENZOYL-L-TARTRATE CRYSTAL FORM, PREPARATION METHOD AND USE
Document Type and Number:
WIPO Patent Application WO/2024/017170
Kind Code:
A1
Abstract:
A S-(-)-nicotine(-)-dibenzoyl-L-tartrate crystal form, a preparation method and a use. The preparation method comprises: respectively dissolving S-(-)-nicotine and (-)-dibenzoyl-L-tartaric acid in solvents, adding the (-)-dibenzoyl-L-tartaric acid solution into the S-(-)-nicotine solution, stirring, and filtering; vacuum drying the filter cake at a certain temperature to obtain a S-(-)-nicotine (-)-dibenzoyl-L-tartrate crystal form. The crystal form of the salt is detected by means of X-RPD and the like, and the crystal form is applied to resolution of racemic nicotine; by controlling process parameters, the isomer content is effectively controlled, the resolution efficiency is improved, and efficient synthesis of S-(-)-nicotine is achieved.
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Inventors:
LIN SHAOHUI (CN)
HU YONGWEI (CN)
HU YONGWEI (CN)
Application Number:
PCT/CN2023/107560
Publication Date:
January 25, 2024
Filing Date:
July 14, 2023
Export Citation:
Assignee:
BEIJING SCIECURE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/04; C07C67/52; C07C69/78
Foreign References:
| CN115093394A | 2022-09-23 | |||
| CN111187250A | 2020-05-22 | |||
| CN111511726A | 2020-08-07 | |||
| CN111004212A | 2020-04-14 | |||
| CN113416180A | 2021-09-21 | |||
| CN114249711A | 2022-03-29 | |||
| CN111527077A | 2020-08-11 | |||
| US20120197022A1 | 2012-08-02 | |||
| US20190263777A1 | 2019-08-29 |
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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