S-(+)-PRANOPROFEN DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF

Title:

S-(+)-PRANOPROFEN DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/122859

Kind Code:

A1

Abstract:

Disclosed are an S-(+)-pranoprofen derivative, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof. The provided S-(+)-pranoprofen derivative has excellent salt formability, so that solubility is improved by 20-30 times; in addition, the S-(+)-pranoprofen derivative has relatively high stability, relatively high safety, and small eye irritability, has a more excellent analgesic effect, is suitable for being developed into a plurality of dosage forms, and has a good medical application prospect.

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Inventors:

ZHANG ZHEFENG (CN)
ZHAO KAI (CN)
FU HAIJIAN (CN)
LI HAIDE (CN)
QIN ZHIQIAO (CN)

Application Number:

PCT/CN2021/141503

Publication Date:

July 06, 2023

Filing Date:

December 27, 2021

Export Citation:

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Assignee:

NANJING ZHIHE MEDICINE TECH CO LTD (CN)

International Classes:

C07D491/052; A61K31/435; A61P1/02; A61P19/02; A61P27/02; A61P29/00

Foreign References:

JPH02289516A	1990-11-29
CN109053749A	2018-12-21

Other References:

JEE UNG KIL: "Pharmaceutical Study on Pranoprofen Argininate and Pranoprofen Lysinate", J. KOR. SCI., vol. 17, no. 4, 1 January 1987 (1987-01-01), pages 197 - 204, XP093075264

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