Title:
S100A8-INHIBITING PEPTIDE AND THERAPEUTIC DRUG FOR DISEASE WHICH CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2021/246265
Kind Code:
A1
Abstract:
A S100A8-inhibiting peptide comprises (A) a peptide which comprises a portion of the amino acid sequence represented by SEQ ID NO: 1, contains an alanine (Ala) residue located at position-5 from the N-terminal of the aforementioned amino acid sequence, and has a length composed of 5 to 10 residues or (B) a peptide which comprises the amino acid sequence represented by SEQ ID NO: 2.
Inventors:
MARU YOSHIRO (JP)
DEGUCHI ATSUKO (JP)
NISHIKAWA KIYOTAKA (JP)
TAKAHASHI MIHO (JP)
OHTO UMEHARU (JP)
DEGUCHI ATSUKO (JP)
NISHIKAWA KIYOTAKA (JP)
TAKAHASHI MIHO (JP)
OHTO UMEHARU (JP)
Application Number:
PCT/JP2021/020095
Publication Date:
December 09, 2021
Filing Date:
May 26, 2021
Export Citation:
Assignee:
UNIV TOKYO WOMENS MEDICAL (JP)
THE DOSHISHA (JP)
THE DOSHISHA (JP)
International Classes:
C07K7/06; A61K38/08; A61P1/04; A61P3/00; A61P17/00; A61P25/18; A61P29/00; A61P31/14; A61P35/04; A61P37/08; A61P43/00; C07K19/00
Foreign References:
| JP2020083759A | 2020-06-04 | |||
| JP5718574B2 | 2015-05-13 |
Other References:
DEGUCHI A; TOMITA T; OHTO U; TAKEMURA K; KITAO A; AKASHI-TAKAMURA S; MIYAKE K; MARU Y: "Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 35, no. 11, 1 January 1900 (1900-01-01), London , pages 1445 - 1456, XP037324348, ISSN: 0950-9232, DOI: 10.1038/onc.2015.211
BERTHIER SYLVIE, NGUYEN MINH VU CHUONG, BAILLET ATHAN, HOGRAINDLEUR MARC-ANDRÉ, PACLET MARIE-HÉLÈNE, POLACK BENOÎT, MOREL FRANÇOIS: "Molecular Interface of S100A8 with Cytochrome b558 and NADPH Oxidase Activation", PLOS ONE, vol. 7, no. 7, 10 July 2012 (2012-07-10), pages e40277, XP055880554, DOI: 10.1371/journal.pone.0040277
HIRATSUKA ET AL., NAT CELL BIOL, vol. 8, 2006, pages 1369 - 1375
HIRATSUKA ET AL., NAT COMMUN, vol. 4, 2013, pages 1853
DEGUCHI ET AL., ONCOGENE, vol. 35, 2016, pages 1445 - 1456
SEKIMOTO ET AL., PNAS, vol. 112, 2015, pages 2058
NIE ET AL., NEURON, vol. 99, 2018, pages 464
ZHOU ET AL., CELL HOST AND MICROBE, 2020
BERTHIER SYLVIE, NGUYEN MINH VU CHUONG, BAILLET ATHAN, HOGRAINDLEUR MARC-ANDRÉ, PACLET MARIE-HÉLÈNE, POLACK BENOÎT, MOREL FRANÇOIS: "Molecular Interface of S100A8 with Cytochrome b558 and NADPH Oxidase Activation", PLOS ONE, vol. 7, no. 7, 10 July 2012 (2012-07-10), pages e40277, XP055880554, DOI: 10.1371/journal.pone.0040277
HIRATSUKA ET AL., NAT CELL BIOL, vol. 8, 2006, pages 1369 - 1375
HIRATSUKA ET AL., NAT COMMUN, vol. 4, 2013, pages 1853
DEGUCHI ET AL., ONCOGENE, vol. 35, 2016, pages 1445 - 1456
SEKIMOTO ET AL., PNAS, vol. 112, 2015, pages 2058
NIE ET AL., NEURON, vol. 99, 2018, pages 464
ZHOU ET AL., CELL HOST AND MICROBE, 2020
Attorney, Agent or Firm:
ONO Yuki et al. (JP)
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