STABILIZED HUMAN IgG1 AND IgG3 ANTIBODIES

Title:

STABILIZED HUMAN IgG1 AND IgG3 ANTIBODIES

Document Type and Number:

WIPO Patent Application WO/2006/075668

Kind Code:

A1

Abstract:

An IgG heavy chain having at least the substitution of F at position 300 for Y, V at position 309 for L or T at position 339 for A in the constant region of a human IgG2 heavy chain; an IgG heavy chain having at least the substitution of N at position 392 for K or M at position 397 for V in the constant region of a human IgG3 wherein the amino acid numbering is made according to the EU index as in Kabat; and monoclonal antibodies having these heavy chains. It is possible to to produce highly stable variants of human antibodies IgG2 and IgG3 subclasses.

Inventors:

TAKAHASHI NOBUAKI (JP)
YOSHIDA HIDEAKI (JP)

Application Number:

PCT/JP2006/300307

Publication Date:

July 20, 2006

Filing Date:

January 12, 2006

Export Citation:

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Assignee:

KIRIN BREWERY (JP)
TAKAHASHI NOBUAKI (JP)
YOSHIDA HIDEAKI (JP)

International Classes:

C12N15/02; A61K39/395; A61P31/00; A61P35/00; A61P37/02; C07K16/28; C12P21/08

Domestic Patent References:

WO2002088186A1	2002-11-07
WO2003040170A2	2003-05-15
WO2005063981A1	2005-07-14

Other References:

See also references of EP 1847602A4
None

Attorney, Agent or Firm:

Hiraki, Yusuke (3-20 Toranomon 4-chome, Minato-k, Tokyo 01, JP)

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