Title:
SACUBITRIL INTERMEDIATE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/206874
Kind Code:
A1
Abstract:
A sacubitril intermediate, a preparation method therefor, and use thereof. A key intermediate N-Boc amino alcohol represented by formula (10) or formula (10-a) can be efficiently prepared. The intermediate can be used to prepare a neutral endopeptidase (NEP) inhibitor or a prodrug thereof, particularly a NEP inhibitor comprising a skeleton of γ-amino-δ-biphenyl-α-methylalkanoic acid or ester, such as sacubitril. Also provided are intermediates for preparing formula (10) or formula (10-a). Raw materials of the process route are cheap, the operation is simple and convenient, the production cost is low, and the method is suitable for industrial production.
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Inventors:
LANG QIWEI (CN)
ZHAO JINHUI (CN)
LIU CHUANGJI (CN)
ZHANG ZIHENG (CN)
DING XIAOBING (CN)
ZHAO JINHUI (CN)
LIU CHUANGJI (CN)
ZHANG ZIHENG (CN)
DING XIAOBING (CN)
Application Number:
PCT/CN2022/114100
Publication Date:
November 02, 2023
Filing Date:
August 23, 2022
Export Citation:
Assignee:
SHENZHEN CATALYST TECH CO LTD (CN)
International Classes:
C07C269/04; C07C213/00; C07C215/28; C07C269/06; C07C271/14; C07C271/16; C07D203/02; C07D203/20; C07D263/22
Foreign References:
| CN105237560A | 2016-01-13 | |||
| CN108047092A | 2018-05-18 | |||
| US20040049074A1 | 2004-03-11 | |||
| CN113637009A | 2021-11-12 | |||
| CN105085322A | 2015-11-25 | |||
| CN102485718A | 2012-06-06 |
Attorney, Agent or Firm:
GUANGDONG JINTAI ZHIHUI PATENT & TRADEMARK AGENCY (GENERAL PARTNERSHIP) (CN)
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