Title:
SAFRAMYCINS, ANALOGUES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2002040477
Kind Code:
A3
Abstract:
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods for the synthesis thereof (I), In another aspect, the present invention provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. In yet another aspect, the present invention provides methods for treating cancer comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof.
Inventors:
MYERS ANDREW (US)
PLOWRIGHT ALLEYN T (GB)
KUNG DANIEL W (US)
LANMAN BRIAN (US)
PLOWRIGHT ALLEYN T (GB)
KUNG DANIEL W (US)
LANMAN BRIAN (US)
Application Number:
PCT/US2001/047399
Publication Date:
February 27, 2003
Filing Date:
November 05, 2001
Export Citation:
Assignee:
HARVARD COLLEGE (US)
MYERS ANDREW (US)
PLOWRIGHT ALLEYN T (GB)
KUNG DANIEL W (US)
LANMAN BRIAN (US)
MYERS ANDREW (US)
PLOWRIGHT ALLEYN T (GB)
KUNG DANIEL W (US)
LANMAN BRIAN (US)
International Classes:
A61K31/4995; A61P35/00; A61P35/04; C07D471/18; (IPC1-7): A61K31/495; C07D471/18
Domestic Patent References:
| WO2000018233A1 | 2000-04-06 | |||
| WO2001053299A1 | 2001-07-26 |
Other References:
HILL ET AL.: "Computer Simulation ...", J.MED.CHEM., vol. 34, 1991, pages 1990 - 1998, XP002206549
MARTINEZ E J ET AL: "A NEW, MORE EFFICIENT, AND EFFECTIVE PROCESS FOR THE SYNTHESIS OF A KEY PENTACYCLIC INTERMEDIATE FOR PRODUCTION OF ECTEINASCIDIN AND PHTHALASCIDIN ANTITUMOR AGENTS", ORGANIC LETTERS, ACS, WASHINGTON, DC, US, vol. 2, no. 7, 2000, pages 993 - 996, XP002940455, ISSN: 1523-7060
MEYERS ET AL.: "One-step construction of the pentacyclic ...", ORG.LETT., vol. 2, no. 9, 23 August 2000 (2000-08-23), pages 3019 - 3022, XP002206550
MEYERS ET AL.: "A concise, stereocontrolled synthesis...", J.AM.CHEM.SOC., vol. 121, 1999, pages 10828 - 10829, XP002206551
FUKUYAMA T ET AL: "TOTAL SYNTHESIS OF (PLUS OR MINUS)-SAFRAMYCIN A", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 112, no. 9, April 1990 (1990-04-01), pages 3712 - 3713, XP002925425, ISSN: 0002-7863
KUBO ET AL.: "Synthesis of saframycins...", CHEM.PHARM.BULL, vol. 35, no. 5, 1987, pages 2158 - 2161, XP002206552
PATENT ABSTRACTS OF JAPAN vol. 012, no. 202 (C - 503) 10 June 1988 (1988-06-10)
SAITO N ET AL: "SYNTHESIS OF SAFRAMYCINS. VII. THE SYNTHESIS OF NOVEL RENIERAMYCIN CONGENERS", HETEROCYCLES, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 32, no. 6, 1991, pages 1203 - 1214, XP001036954, ISSN: 0385-5414
SAITO ET AL.: "Synthesis of saframycins...", TETREHEDRON, vol. 51, no. 30, 1995, pages 8213 - 8230, XP002206553
SAITO ET AL.: "Synthesis of saframycins...", TETRAHEDRON, vol. 51, no. 20, 1995, pages 8231 - 8246, XP002206554
FUKUYAMA T ET AL: "STEREOCONTROLLED TOTAL SYNTHESIS OF (PLUS OR MINUS)-SAFRAMYCIN B", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, XX, XX, vol. 104, 1982, pages 4957 - 4958, XP000942669, ISSN: 0002-7863
SAITO N ET AL: "SYNTHESIS OF SAFRAMYCINS X. TRANSFORMATION OF (-)-SAFRAMYCIN A TO (-)-SAFRAMYCIN MX TYPE COMPOUND WITH THE STRUCTURE PROPOSED FOR SAFRAMYCIN E", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 43, no. 5, May 1995 (1995-05-01), pages 777 - 782, XP001037150, ISSN: 0009-2363
SAITO ET AL.: "Synthesis of saframycins...", CHEM.PHARM.BULL., vol. 39, no. 5, 1991, pages 1343 - 1345, XP002206555
SAKAI R ET AL: "ECTEINASCIDINS: PUTATIVE BIOSYNTHETIC PRECURSORS AND ABSOLUTE STEREOCHEMISTRY", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 118, 1996, pages 9017 - 9023, XP000942122, ISSN: 0002-7863
MYERS ET AL.: "Synthesis and evaluation...", J.AM.CHEM.SOC., vol. 123, 8 May 2001 (2001-05-08), pages 5114 - 5115, XP002206556
MARTINEZ E J ET AL: "A NEW, MORE EFFICIENT, AND EFFECTIVE PROCESS FOR THE SYNTHESIS OF A KEY PENTACYCLIC INTERMEDIATE FOR PRODUCTION OF ECTEINASCIDIN AND PHTHALASCIDIN ANTITUMOR AGENTS", ORGANIC LETTERS, ACS, WASHINGTON, DC, US, vol. 2, no. 7, 2000, pages 993 - 996, XP002940455, ISSN: 1523-7060
MEYERS ET AL.: "One-step construction of the pentacyclic ...", ORG.LETT., vol. 2, no. 9, 23 August 2000 (2000-08-23), pages 3019 - 3022, XP002206550
MEYERS ET AL.: "A concise, stereocontrolled synthesis...", J.AM.CHEM.SOC., vol. 121, 1999, pages 10828 - 10829, XP002206551
FUKUYAMA T ET AL: "TOTAL SYNTHESIS OF (PLUS OR MINUS)-SAFRAMYCIN A", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 112, no. 9, April 1990 (1990-04-01), pages 3712 - 3713, XP002925425, ISSN: 0002-7863
KUBO ET AL.: "Synthesis of saframycins...", CHEM.PHARM.BULL, vol. 35, no. 5, 1987, pages 2158 - 2161, XP002206552
PATENT ABSTRACTS OF JAPAN vol. 012, no. 202 (C - 503) 10 June 1988 (1988-06-10)
SAITO N ET AL: "SYNTHESIS OF SAFRAMYCINS. VII. THE SYNTHESIS OF NOVEL RENIERAMYCIN CONGENERS", HETEROCYCLES, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 32, no. 6, 1991, pages 1203 - 1214, XP001036954, ISSN: 0385-5414
SAITO ET AL.: "Synthesis of saframycins...", TETREHEDRON, vol. 51, no. 30, 1995, pages 8213 - 8230, XP002206553
SAITO ET AL.: "Synthesis of saframycins...", TETRAHEDRON, vol. 51, no. 20, 1995, pages 8231 - 8246, XP002206554
FUKUYAMA T ET AL: "STEREOCONTROLLED TOTAL SYNTHESIS OF (PLUS OR MINUS)-SAFRAMYCIN B", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, XX, XX, vol. 104, 1982, pages 4957 - 4958, XP000942669, ISSN: 0002-7863
SAITO N ET AL: "SYNTHESIS OF SAFRAMYCINS X. TRANSFORMATION OF (-)-SAFRAMYCIN A TO (-)-SAFRAMYCIN MX TYPE COMPOUND WITH THE STRUCTURE PROPOSED FOR SAFRAMYCIN E", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 43, no. 5, May 1995 (1995-05-01), pages 777 - 782, XP001037150, ISSN: 0009-2363
SAITO ET AL.: "Synthesis of saframycins...", CHEM.PHARM.BULL., vol. 39, no. 5, 1991, pages 1343 - 1345, XP002206555
SAKAI R ET AL: "ECTEINASCIDINS: PUTATIVE BIOSYNTHETIC PRECURSORS AND ABSOLUTE STEREOCHEMISTRY", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 118, 1996, pages 9017 - 9023, XP000942122, ISSN: 0002-7863
MYERS ET AL.: "Synthesis and evaluation...", J.AM.CHEM.SOC., vol. 123, 8 May 2001 (2001-05-08), pages 5114 - 5115, XP002206556
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