Title:
SALICYLAMIDES AS SERINE PROTEASE AND FACTOR XA INHIBITORS
Document Type and Number:
WIPO Patent Application WO2001044172
Kind Code:
A8
Abstract:
The present invention provides novel compounds of Formula (I), its prodrug forms, or pharmaceutically acceptable salts thereof. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa), and have utility as anti cancer agents and/or as anticoagulants for the treatment or prevention of thromboembolic disorders in mammals. The present invention also provides a process for the selective acylation of an amino group.
Inventors:
ALLEN DARIN ARTHUR (US)
MCGEE DANNY PETER CLAUDE (US)
SPENCER JEFFREY R (US)
MCGEE DANNY PETER CLAUDE (US)
SPENCER JEFFREY R (US)
Application Number:
PCT/US2000/034211
Publication Date:
July 19, 2001
Filing Date:
December 14, 2000
Export Citation:
Assignee:
AXYS PHARM INC (US)
ALLEN DARIN ARTHUR (US)
MCGEE DANNY PETER CLAUDE (US)
SPENCER JEFFREY R (US)
ALLEN DARIN ARTHUR (US)
MCGEE DANNY PETER CLAUDE (US)
SPENCER JEFFREY R (US)
International Classes:
A61P7/02; A61P35/00; C07C257/18; C07C279/18; C07D209/48; C07D213/75; C07D235/06; C07D235/08; C07D307/14; C07D317/60; C07D401/12; (IPC1-7): C07C257/18; A61K31/155; A61P7/02; A61P35/00; C07C279/18
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