Title:
SALICYLIC ACID-BASED FUMARATE DERIVATIVE AND USE IN TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES
Document Type and Number:
WIPO Patent Application WO/2018/177114
Kind Code:
A1
Abstract:
The new compound provided by the applicant is a salicylic acid-based fumarate derivative having a general structural formula (A): wherein in the general structural formula (A), R1 is one of H+, Na+, K+ or NH4+, and R2 is an esterified product of fumaric acid. According to the experimental verification by the applicant, the salicylic acid-based fumarate derivative has the general structural formula formed by combining salicylic acid and fumaric acid via an esterification reaction. It is proven that such a compound has a good activity in the treatment of neurodegenerative diseases.
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Inventors:
YANG LICHUAN (US)
THOMAS BOBBY (US)
GUO MINGYUE (CN)
THOMAS BOBBY (US)
GUO MINGYUE (CN)
Application Number:
PCT/CN2018/078618
Publication Date:
October 04, 2018
Filing Date:
March 09, 2018
Export Citation:
Assignee:
CHONGQING NEUROPARK BIRSCIENCE CO LTD (CN)
International Classes:
C07C67/29; A61K31/222; A61P25/00; A61P25/16; C07C69/60
Domestic Patent References:
| WO2014052889A1 | 2014-04-03 |
Foreign References:
| CN104710314A | 2015-06-17 | |||
| CN105142628A | 2015-12-09 | |||
| US20140194427A1 | 2014-07-10 |
Other References:
WU, XIAO-AI: "Lithium Chloride - Assisted Selective Hydrolysis of Methyl Esters Under Microwave Irradiation", SYNTHETIC COMMUNICATIONS, vol. 39, no. 19, 4 September 2009 (2009-09-04), pages 3459 - 3470, XP055612488, DOI: 10.1080/00397910902778001
RECASENS ADEHAY BBOVE J ET AL.: "Lewy body extracts from Parkinson disease brains trigger-synuclein pathology and neurodegeneration in mice and monkeys", ANNALS OF NEUROLOGY, vol. 75, 2014, pages 351 - 362
UNTERBERGER ULACHMANN IVOITLANDER T. ET AL.: "Detection of disease-associated alpha-synuclein in the cerebrospinal fluid: a feasibility study", NEUROBIOLOGY OF DISEASE, vol. 33, 2014, pages 329 - 334
MANUJ AHUJANAVNEET AMMAL KAIDERYLICHUAN YANGNOEL CALINGASANNATALYA SMIRNOVAARSEN GAISINIRINA NGAISINA, IRINA GAZARYANDMITRY M. HUS: "Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Pheny1-1,2,3,6-Tetrahydropyridine Induced Experimental Parkinson's-Like Disease", THE JOURNAL OF NEUROSCIENCE, vol. 36, no. 23, 2016, pages 6332 - 6351
See also references of EP 3611157A4
RECASENS ADEHAY BBOVE J ET AL.: "Lewy body extracts from Parkinson disease brains trigger-synuclein pathology and neurodegeneration in mice and monkeys", ANNALS OF NEUROLOGY, vol. 75, 2014, pages 351 - 362
UNTERBERGER ULACHMANN IVOITLANDER T. ET AL.: "Detection of disease-associated alpha-synuclein in the cerebrospinal fluid: a feasibility study", NEUROBIOLOGY OF DISEASE, vol. 33, 2014, pages 329 - 334
MANUJ AHUJANAVNEET AMMAL KAIDERYLICHUAN YANGNOEL CALINGASANNATALYA SMIRNOVAARSEN GAISINIRINA NGAISINA, IRINA GAZARYANDMITRY M. HUS: "Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Pheny1-1,2,3,6-Tetrahydropyridine Induced Experimental Parkinson's-Like Disease", THE JOURNAL OF NEUROSCIENCE, vol. 36, no. 23, 2016, pages 6332 - 6351
See also references of EP 3611157A4
Attorney, Agent or Firm:
CHONGQING PHAETON LAWFIRM (CN)
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