Title:
SALT OF DIOXYGENASE INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/057104
Kind Code:
A1
Abstract:
The present invention relates to a salt of a dioxygenase inhibitor and a preparation method therefor and the use thereof, in particular relates to a salt of (Z)-N-(3-bromo-4-fluoro-phenyl)-4-((2-(N-(cyclopropylsulfonyl)-S-methylsulfinylimine)ethyl)amino)-N'-hydroxy-1,2,5-oxadiazole-3-carboxamidine having the structure of general formula (I), a preparation method therefor and the use thereof, and a pharmaceutical composition comprising a therapeutic effective amount of the salt. The salt can be widely used to treat or prevent cancers or tumours, virus infections, depression, neurodegenerative disease, trauma, age-related cataract, organ-graft refection or autoimmune diseases, and is expected to be developed into a new generation of immunosuppressors, wherein the definition of each substituent in the general formula (I) is the same as defined in the description.
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Inventors:
GUO LINSONG (CN)
LIU FUPING (CN)
LIU FUPING (CN)
Application Number:
PCT/CN2018/106652
Publication Date:
March 28, 2019
Filing Date:
September 20, 2018
Export Citation:
Assignee:
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D271/08; A61K31/4245; A61P35/00
Domestic Patent References:
| WO2017181849A1 | 2017-10-26 | |||
| WO2016041489A1 | 2016-03-24 | |||
| WO2010005958A2 | 2010-01-14 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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