SALT OF QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Title:

SALT OF QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/054359

Kind Code:

A1

Abstract:

A salt of a quinazoline derivative (N-[4-(3-chlorine-fluoanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.

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Inventors:

XIA GUANGXIN (CN)
LI DI (CN)
ZHOU NING (CN)
CHEN AO (CN)
ZHAO LIANG (CN)
HAN JIANSHENG (CN)
LIU YANJUN (CN)

Application Number:

PCT/CN2017/102998

Publication Date:

March 29, 2018

Filing Date:

September 22, 2017

Export Citation:

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Assignee:

SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN)

International Classes:

C07D239/94; A61K31/517; A61K31/5377; A61P35/00; C07D401/12; C07D403/12; C07D405/12; C07D413/12; C07F9/6512; C07F9/6558

Foreign References:

CN102898386A	2013-01-30
CN103965120A	2014-08-06
CN104109166A	2014-10-22
CN102020639A	2011-04-20
CN1745073A	2006-03-08

Other References: