SALT OF SUBSTITUTED AMINO SIX-MEMBERED NITRIC HETEROCYCLIC COMPOUND, CRYSTAL FORM THEREOF, METHOD FOR PREPARING SAME, AND USE THEREOF

Title:

SALT OF SUBSTITUTED AMINO SIX-MEMBERED NITRIC HETEROCYCLIC COMPOUND, CRYSTAL FORM THEREOF, METHOD FOR PREPARING SAME, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/174400

Kind Code:

A1

Abstract:

The present invention provides a salt of a substituted amino six-membered nitric heterocyclic compound, a crystal form thereof, a method for preparing same, and use thereof. Specifically provided is a dihydrochloride salt of a compound represented by formula (I). The salt can be prepared as a crystal form, the crystal form preferably having the following advantages: good solubility, low hygroscopicity, stable quality, and crystal form stability, thus being more easily developed into drugs as compared with the compound represented by formula (I) or other salts.

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Inventors:

ZHANG AO (CN)
LI ZHIHUAI (CN)
HAO HONGRU (CN)
GENG MEIYU (CN)
CAO ZEFENG (CN)
SONG ZILAN (CN)
HE YING (CN)
YIN LU (CN)

Application Number:

PCT/CN2023/082140

Publication Date:

September 21, 2023

Filing Date:

March 17, 2023

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Assignee:

SHANGHAI RUNSHI MEDICAL TECH CO LTD (CN)
SHANGHAI INST MATERIA MEDICA CAS (CN)

International Classes:

C07D401/12; A61K31/444; A61K31/496; A61P35/00; C07D213/63; C07D213/75

Domestic Patent References:

WO2016027780A1

2016-02-25

Foreign References:

CN107098884A	2017-08-29
CN105073730A	2015-11-18
CN102639510A	2012-08-15
CN106660997A	2017-05-10
CN108699030A	2018-10-23
CN113318110A	2021-08-31

Other References:

WEI MANMAN, XIA PENG, LI XING, YANG DAI, RUIMIN HUANG, MEIYU GENG, AO ZHANG, JING AI, ZILAN SONG: "Design, Synthesis and Biological Evaluation of a Series of Novel 2-Benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine Derivatives as Potent Fibroblast Growth Factor Receptor (FGFR) Inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 154, 16 May 2018 (2018-05-16), pages 9 - 28, XP055841883, DOI: 10.1016/j.ejmech.2018.05.005

Attorney, Agent or Firm:

BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)

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