Title:
THE SALTS OF 3-(4-AMINO-1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)PIPERIDINE-2,6-DIONE OR ITS DERIVATIVES, THEIR POLYMORPHS, PREPARATION METHODS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/111948
Kind Code:
A1
Abstract:
The present invention provides the pharmaceutically acceptable strong acid addition salts of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)piperidine-2,6-dione, their solvates, preparation methods and uses of treating the diseases or abnormities of inhibiting inflammatory gene or new blood vessel formation . The water-solubility of the pharmaceutically acceptable strong acid addition salts of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)piperidine-2,6-dione is higher than 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)piperidine-2,6-dione. The present invention also provides the polymorphs of the pharmaceutically acceptable strong acid addition salts of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)piperidine-2,6-dione and their solvates.
Inventors:
ZHANG HESHENG
Application Number:
PCT/CN2009/000258
Publication Date:
September 17, 2009
Filing Date:
March 11, 2009
Export Citation:
Assignee:
TIANJIN HEMAY BIO TECH CO LTD (CN)
ZHANG HESHENG
ZHANG HESHENG
International Classes:
C07D401/04; A61K31/454; A61P1/00; A61P1/16; A61P9/00; A61P11/00; A61P13/00; A61P17/00; A61P17/06; A61P19/00; A61P25/16; A61P29/00; A61P35/00; A61P37/00; C07D209/46; C07D211/88
Domestic Patent References:
| WO2007005972A1 | 2007-01-11 |
Foreign References:
| CN1575174A | 2005-02-02 | |||
| US5874448A | 1999-02-23 |
Attorney, Agent or Firm:
TIANJIN CAIZHI PATENT & TRADEMARK AGENCY, LTD (Building AYunlangxinju,No. 149, Weijin Road,Heping District, Tianjin 0, CN)
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