Title:
SARM1 MODULATORS, PREPARATIONS, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/072026
Kind Code:
A1
Abstract:
Provided herein are compounds of Formula (I), compositions comprising the same, and methods of using the same, including use in treating various diseases and conditions, e.g., those caused by axonal degeneration.
Inventors:
ZHANG ZHIYUAN (CN)
ZHANG ZHAOLAN (CN)
SUN WEIDONG (CN)
XU YANPING (CN)
JIANG YIMIN (CN)
LIU LIANZHU (CN)
ZHANG ZHAOLAN (CN)
SUN WEIDONG (CN)
XU YANPING (CN)
JIANG YIMIN (CN)
LIU LIANZHU (CN)
Application Number:
PCT/CN2022/127233
Publication Date:
May 04, 2023
Filing Date:
October 25, 2022
Export Citation:
Assignee:
SIRONAX LTD (GB)
ZHANG ZHIYUAN (CN)
ZHANG ZHIYUAN (CN)
International Classes:
C07D213/16; A61K31/44; A61K31/4427; A61P25/14; A61P25/16; C07D403/04; C07D413/04
Domestic Patent References:
| WO2018057989A1 | 2018-03-29 | |||
| WO2020081923A1 | 2020-04-23 | |||
| WO2020142485A1 | 2020-07-09 |
Other References:
DATABASE Registry CAS; 24 July 2020 (2020-07-24), XP093077332, Database accession no. 1159816-56-4
BOSANAC TODD, HUGHES ROBERT O, ENGBER THOMAS, DEVRAJ RAJESH, BREARLEY ANDREW, DANKER KERSTIN, YOUNG KENNETH, KOPATZ JENS, HERMANN : "Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy", BRAIN, vol. 144, no. 10, 29 November 2021 (2021-11-29), GB , pages 3226 - 3238, XP093062730, ISSN: 0006-8950, DOI: 10.1093/brain/awab184
HUGHES，R. ET AL.: "Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate.", CELL REP., vol. 34, no. 1, 5 January 2021 (2021-01-05), XP055945899, DOI: 10.1016/j.celrep.2020.108588
BOSANAC TODD, HUGHES ROBERT O, ENGBER THOMAS, DEVRAJ RAJESH, BREARLEY ANDREW, DANKER KERSTIN, YOUNG KENNETH, KOPATZ JENS, HERMANN : "Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy", BRAIN, vol. 144, no. 10, 29 November 2021 (2021-11-29), GB , pages 3226 - 3238, XP093062730, ISSN: 0006-8950, DOI: 10.1093/brain/awab184
HUGHES，R. ET AL.: "Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate.", CELL REP., vol. 34, no. 1, 5 January 2021 (2021-01-05), XP055945899, DOI: 10.1016/j.celrep.2020.108588
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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