Title:
SARS-COV-2 INHIBITORS HAVING COVALENT MODIFICATIONS FOR TREATING CORONAVIRUS INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2021/219089
Kind Code:
A1
Abstract:
Provided herein are compounds, pharmaceutical compositions and methods for treating a SARS-CoV-2 infection.
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Inventors:
ZAVORONKOVS ALEKSANDRS (CN)
IVANENKOV YAN A (CN)
ZAGRIBELNYY BOGDAN (CN)
IVANENKOV YAN A (CN)
ZAGRIBELNYY BOGDAN (CN)
Application Number:
PCT/CN2021/091093
Publication Date:
November 04, 2021
Filing Date:
April 29, 2021
Export Citation:
Assignee:
INSILICO MEDICINE IP LTD (CN)
International Classes:
C07D323/04; A61K31/381; A61K31/4965; A61K31/505; A61P31/14; C07D275/02
Foreign References:
| US20170313685A1 | 2017-11-02 |
Other References:
GUL SEREF, OZCAN ONUR, ASAR SINAN, OKYAR ALPER, BARIS IBRAHIM, KAVAKLI IBRAHIM HALIL: "In silico identification of widely used and well-tolerated drugs as potential SARS-CoV-2 3C-like protease and viral RNA-dependent RNA polymerase inhibitors for direct use in clinical trials", JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, vol. 39, no. 17, US , pages 6772 - 6791, XP055862677, ISSN: 0739-1102, DOI: 10.1080/07391102.2020.1802346
JON JACOBS, VALERIE GRUM-TOKARS, YA ZHOU, MARK TURLINGTON, S. ADRIAN SALDANHA, PETER CHASE, AIMEE EGGLER, ERIC S. DAWSON, YAHIRA M: "Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 2, 24 January 2013 (2013-01-24), US , pages 534 - 546, XP055333594, ISSN: 0022-2623, DOI: 10.1021/jm301580n
ABUHAMMAD AREEJ, AL‐AQTASH RUA'A A., ANSON BRANDON J., MESECAR ANDREW D., TAHA MUTASEM O.: "Computational modeling of the bat HKU4 coronavirus 3CL pro-inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS)coronavirus", JOURNAL OF MOLECULAR RECOGNITION, vol. 30, no. 11, 1 November 2017 (2017-11-01), GB , XP055826350, ISSN: 0952-3499, DOI: 10.1002/jmr.2644
TURLINGTON， M. ET AL.，: "Discovery of N-(benzo[1，2，3]triazol-1-yl)-N-(benzyl)acetam ido) coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding，", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, 7 December 2013 (2013-12-07), pages 6172 - 6177, XP028755251
JOHN，SARAH E. ST. ET AL.，: "X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus，", SCIENTIFIC REPORTS, vol. 6, 13 May 2016 (2016-05-13), pages 1 - 10, XP055862685
JOHN， SARAH E. ST. ET AL.，: "Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)，", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, 19 June 2015 (2015-06-19), pages 6036 - 6048, XP055826372, DOI: 10.1016/j.bmc.2015.06.039
JON JACOBS, VALERIE GRUM-TOKARS, YA ZHOU, MARK TURLINGTON, S. ADRIAN SALDANHA, PETER CHASE, AIMEE EGGLER, ERIC S. DAWSON, YAHIRA M: "Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 2, 24 January 2013 (2013-01-24), US , pages 534 - 546, XP055333594, ISSN: 0022-2623, DOI: 10.1021/jm301580n
ABUHAMMAD AREEJ, AL‐AQTASH RUA'A A., ANSON BRANDON J., MESECAR ANDREW D., TAHA MUTASEM O.: "Computational modeling of the bat HKU4 coronavirus 3CL pro-inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS)coronavirus", JOURNAL OF MOLECULAR RECOGNITION, vol. 30, no. 11, 1 November 2017 (2017-11-01), GB , XP055826350, ISSN: 0952-3499, DOI: 10.1002/jmr.2644
TURLINGTON， M. ET AL.，: "Discovery of N-(benzo[1，2，3]triazol-1-yl)-N-(benzyl)acetam ido) coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding，", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, 7 December 2013 (2013-12-07), pages 6172 - 6177, XP028755251
JOHN，SARAH E. ST. ET AL.，: "X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus，", SCIENTIFIC REPORTS, vol. 6, 13 May 2016 (2016-05-13), pages 1 - 10, XP055862685
JOHN， SARAH E. ST. ET AL.，: "Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)，", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, 19 June 2015 (2015-06-19), pages 6036 - 6048, XP055826372, DOI: 10.1016/j.bmc.2015.06.039
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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