Title:
SARS-COV-2 INHIBITORS FOR TREATING CORONAVIRUS INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2023/078231
Kind Code:
A1
Abstract:
Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.
Inventors:
DING XIAO (CN)
PENG JINGJING (CN)
REN FENG (CN)
DING XIAOYU (CN)
ZAGRIBELNYY BOGDAN (RU)
IVANENKOV YAN A (RU)
PENG JINGJING (CN)
REN FENG (CN)
DING XIAOYU (CN)
ZAGRIBELNYY BOGDAN (RU)
IVANENKOV YAN A (RU)
Application Number:
PCT/CN2022/128916
Publication Date:
May 11, 2023
Filing Date:
November 01, 2022
Export Citation:
Assignee:
INSILICO MEDICINE IP LTD (CN)
International Classes:
C07D239/02; A61K31/435; A61K31/495; A61P31/14; C07D401/02; C07D403/02
Domestic Patent References:
| WO2021219089A1 | 2021-11-04 | |||
| WO2022119756A1 | 2022-06-09 | |||
| WO2010151799A2 | 2010-12-29 |
Foreign References:
| US20170313685A1 | 2017-11-02 |
Other References:
YAMANE DAIKI, SATSUKI ONITSUKA, SUYONG RE, HIKARU ISOGAI, RUI HAMADA, TADANARI HIRAMOTO, EIJI KAWANISHI, KENJI MIZUGUCHI, NAOYA SH: "Selective Covalent Targeting of SARS-CoV-2 Main Protease by 2 Enantiopure Chlorofluoroacetamide ", CHEMRXIV, 28 September 2021 (2021-09-28), XP093062257, Retrieved from the Internet [retrieved on 20230710]
STILLE JULIA, JEVGENIJS TJUTRINS, GUANYU WANG, FELIPE A. VENEGAS, CHRISTOPHER HENNECKER, ANDRES MAURICIO RUEDA, CAITLIN E. MIRON, : "Design, synthesis and biological evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors.", CHEMRXIV, 1 April 2021 (2021-04-01), pages 1 - 31, XP093062258, Retrieved from the Internet [retrieved on 20230710]
WU JINGJING, LI HUI, CAO SONG: "Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation", BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 7, 12 July 2011 (2011-07-12), pages 1070 - 1074, XP093062259, DOI: 10.3762/bjoc.7.123
EATON EATON K., LAURA FURST, LUKE L. CAI, VASANTHI S. VISWANATHAN, STUART L. SCHREIBER: "Structure-activity relationships of glutathione peroxidase 4 inhibitor warheads", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 30, no. 23, 11 September 2020 (2020-09-11), XP093062262
JON JACOBS, VALERIE GRUM-TOKARS, YA ZHOU, MARK TURLINGTON, S. ADRIAN SALDANHA, PETER CHASE, AIMEE EGGLER, ERIC S. DAWSON, YAHIRA M: "Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 56, no. 2, 24 January 2013 (2013-01-24), US , pages 534 - 546, XP055333594, ISSN: 0022-2623, DOI: 10.1021/jm301580n
STILLE JULIA, JEVGENIJS TJUTRINS, GUANYU WANG, FELIPE A. VENEGAS, CHRISTOPHER HENNECKER, ANDRES MAURICIO RUEDA, CAITLIN E. MIRON, : "Design, synthesis and biological evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors.", CHEMRXIV, 1 April 2021 (2021-04-01), pages 1 - 31, XP093062258, Retrieved from the Internet
WU JINGJING, LI HUI, CAO SONG: "Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation", BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, vol. 7, 12 July 2011 (2011-07-12), pages 1070 - 1074, XP093062259, DOI: 10.3762/bjoc.7.123
EATON EATON K., LAURA FURST, LUKE L. CAI, VASANTHI S. VISWANATHAN, STUART L. SCHREIBER: "Structure-activity relationships of glutathione peroxidase 4 inhibitor warheads", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 30, no. 23, 11 September 2020 (2020-09-11), XP093062262
JON JACOBS, VALERIE GRUM-TOKARS, YA ZHOU, MARK TURLINGTON, S. ADRIAN SALDANHA, PETER CHASE, AIMEE EGGLER, ERIC S. DAWSON, YAHIRA M: "Discovery, Synthesis, And Structure-Based Optimization of a Series of N -( tert -Butyl)-2-( N -arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 56, no. 2, 24 January 2013 (2013-01-24), US , pages 534 - 546, XP055333594, ISSN: 0022-2623, DOI: 10.1021/jm301580n
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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