Title:
SCREENING METHOD USING THE RZR RECEPTOR FAMILY
Document Type and Number:
WIPO Patent Application WO/1995/027202
Kind Code:
A1
Abstract:
The current invention concerns the use of a receptor from the RZR/ROR receptor family or of a functional fragment thereof in a test of a compound for anti-autoimmune, anti-arthritic, anti-tumor, melatonin-like and/or melatonin-antagonistic activity and the production of a receptor ligand complex comprising said receptor or a functional fragment thereof and a ligand of said receptor. Described is also a method for testing compounds for said activity (screening for ligands) and the active compounds identified therewith.
Inventors:
WIESENBERG IRMGARD (DE)
MISSBACH MARTIN (CH)
MISSBACH MARTIN (CH)
Application Number:
PCT/EP1995/001017
Publication Date:
October 12, 1995
Filing Date:
March 18, 1995
Export Citation:
Assignee:
CIBA GEIGY AG (CH)
WIESENBERG IRMGARD (DE)
MISSBACH MARTIN (CH)
WIESENBERG IRMGARD (DE)
MISSBACH MARTIN (CH)
International Classes:
A61K31/165; A61K31/17; A61K31/18; A61K31/34; G01N33/566; A61K31/343; A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61K31/4184; A61K31/42; A61K31/423; A61K31/535; A61K31/5355; A61K31/536; A61K31/5375; A61K31/5377; A61K31/538; A61K45/00; A61P3/08; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07D209/14; C07D209/30; C07D209/86; C07D235/08; C07D261/20; C07D263/58; C07D265/30; C07D265/36; C07D277/20; C07D277/50; C07D277/68; C07D279/06; C07D307/79; C07D471/04; C07K14/705; C12Q1/68; C12Q1/6897; G01N33/50; G01N33/68; A61K38/00; (IPC1-7): G01N33/50; C12Q1/68; C07K14/705
Domestic Patent References:
| WO1992016546A1 | 1992-10-01 | |||
| WO1992016658A1 | 1992-10-01 |
Foreign References:
| EP0325849A2 | 1989-08-02 | |||
| EP0085275A1 | 1983-08-10 | |||
| EP0585206A1 | 1994-03-02 | |||
| DE2632747A1 | 1977-02-24 | |||
| EP0508955A1 | 1992-10-14 |
Other References:
M.BECKER-ANDRE ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 194, no. 3, 16 August 1993 (1993-08-16), NEW YORK US, pages 1371 - 1379
G.GRAUPNER ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 179, no. 3, 30 September 1991 (1991-09-30), NEW YORK US, pages 1554 - 1561
W.H.M.L.LUYTEN ET AL., TIBTECH, vol. 11, LONDON GB, pages 247 - 254
D.P.MCDONNELL ET AL., BIOTECHNOLOGY, vol. 11, NEW YORK US, pages 1256 - 1261
I. WIESENBERG ET AL., NUCLEIC ACIDS RESEARCH, vol. 23, no. 3, 11 February 1995 (1995-02-11), LONDON GB, pages 327 - 333
M. BECKER-ANDRÉ ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 46, 18 November 1994 (1994-11-18), BALTIMORE US, pages 28531 - 28534
T. HIROSE ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 205, no. 3, 30 December 1994 (1994-12-30), NEW YORK US, pages 1976 - 1983
G.GRAUPNER ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 179, no. 3, 30 September 1991 (1991-09-30), NEW YORK US, pages 1554 - 1561
W.H.M.L.LUYTEN ET AL., TIBTECH, vol. 11, LONDON GB, pages 247 - 254
D.P.MCDONNELL ET AL., BIOTECHNOLOGY, vol. 11, NEW YORK US, pages 1256 - 1261
I. WIESENBERG ET AL., NUCLEIC ACIDS RESEARCH, vol. 23, no. 3, 11 February 1995 (1995-02-11), LONDON GB, pages 327 - 333
M. BECKER-ANDRÉ ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 46, 18 November 1994 (1994-11-18), BALTIMORE US, pages 28531 - 28534
T. HIROSE ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 205, no. 3, 30 December 1994 (1994-12-30), NEW YORK US, pages 1976 - 1983
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