SELECTIVE ANTI-MYCOBACTERIAL PREPARATIONS, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS

WIPO Patent Application WO/1999/059961

A1

The present invention relates to new non-cyclic analogues of crown ethers (podands), principally di(formylaryl)polyethers, as well as to their hydrazones comprising substituted hydrazines of formula (I) where Ar is substituted phenylen or naphtylen, Y is an atom of hydrogen, halogen or a metoxy group, R is an oxygen atom or a NNH-R¿1? group, R¿1? is substituted phenyl, benzoyl or a 2- or 4-nicotinoyl, n is an integer between 1 and 3 and m is an integer between 1 and 4. This invention also relates to pharmaceutically acceptable addition salts and co-ordination compounds used as selective anti-mycobacterial preparations, as well as to a method for producing the same and to pharmaceutical compositions. The compounds of the present invention can essentially be used as an active basis in pharmaceutical preparations used for treating patients affected by mycobacterioses, including tuberculosis. These compounds consist of anti-mycobacterial preparations having a high specificity towards mycobacteria, a high activity against atypical, typical and resistant strains of mycobacteria, as well as a low toxicity. These compounds can be used in practical medicine for treating patients infected by sensitive and resistant as well as by typical and atypical strains of mycobacteria.

CHUPAKHIN OLEG NIKOLAEVICH (RU)
FEDOROVA OLGA VASILIEVNA (RU)
RUSINOV GENNADY LEONIDOVICH (RU)
MORDOVSKOI GEORGY GEORGIEVICH (RU)
KHOMENKO ALEXANDR GRIGORIEVICH (RU)
GOLYSHEVSKAYA VALENTINA IVANOV (RU)
ZUEVA MARINA NIKOLAEVNA (RU)
OVCHINNIKOVA IRINA GEORGIEVNA (RU)

PCT/RU1999/000165

November 25, 1999

May 18, 1999

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INST ORCH SINTEZA URAL OTDEL R (RU)
CHUPAKHIN OLEG NIKOLAEVICH (RU)
FEDOROVA OLGA VASILIEVNA (RU)
RUSINOV GENNADY LEONIDOVICH (RU)
MORDOVSKOI GEORGY GEORGIEVICH (RU)
KHOMENKO ALEXANDR GRIGORIEVICH (RU)
GOLYSHEVSKAYA VALENTINA IVANOV (RU)
ZUEVA MARINA NIKOLAEVNA (RU)
OVCHINNIKOVA IRINA GEORGIEVNA (RU)

C07D213/88; A61K31/115; A61K31/15; A61K31/4402; A61K31/4409; A61K31/455; A61P31/04; A61P31/06; C07C43/20; C07C45/71; C07C47/575; C07C49/86; C07C249/16; C07C251/72; C07C251/86; C07D213/86; C07D401/12; C07F1/06; C07F3/00; (IPC1-7): C07C251/86; A61K31/11; A61K31/15; C07C47/575; C07D213/88; A61K31/351; A61P31/06

WO1993021282A1

1993-10-28

EP0382076A1	1990-08-16
DE4105160A1	1992-08-27
FR2715155A1	1995-07-21
SU287928A
SU607547A3	1978-05-15

Golubeva, Ljudmila Petrovna (37 Ekaterinburg, 2, RU)

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