Title:
SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYL TRANSFERASE 5 (PRMT5)
Document Type and Number:
WIPO Patent Application WO/2018/085833
Kind Code:
A3
Abstract:
The disclosure is directed to compounds of Formula I, Formula II, and Formula III [Formulas should be inserted here]. Methods of their use and preparation are also described.
Inventors:
LUENGO JUAN (US)
LEAL RAUL (US)
LIN HONG (US)
SHETTY RUPA (US)
LEAL RAUL (US)
LIN HONG (US)
SHETTY RUPA (US)
Application Number:
PCT/US2017/060396
Publication Date:
October 25, 2018
Filing Date:
November 07, 2017
Export Citation:
Assignee:
PRELUDE THERAPEUTICS INC (US)
International Classes:
C07D487/04; A61K31/70; C07H19/14; C07H19/167
Domestic Patent References:
| WO2014145214A2 | 2014-09-18 | |||
| WO2016145150A2 | 2016-09-15 | |||
| WO2014172330A1 | 2014-10-23 |
Foreign References:
| EP3103802A1 | 2016-12-14 | |||
| US20120329747A1 | 2012-12-27 |
Other References:
ZHAO QUAN ET AL: "PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing", NAT. STRUCT. MOL. BIOL,, vol. 16, no. 3, 1 March 2009 (2009-03-01), pages 304 - 311, XP002554686, ISSN: 1545-9993, [retrieved on 20090222], DOI: 10.1038/NSMB.1568
WEIHONG ZHENG ET AL: "Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, no. 43, 31 October 2012 (2012-10-31), pages 18004 - 18014, XP055049439, ISSN: 0002-7863, DOI: 10.1021/ja307060p
WEIHONG ZHENG ET AL: "Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, no. 43, 31 October 2012 (2012-10-31), pages 18004 - 18014, XP055049439, ISSN: 0002-7863, DOI: 10.1021/ja307060p
Attorney, Agent or Firm:
DOYLE, Timothy, J. et al. (US)
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