Title:
SELECTIVE LINEAR PEPTIDES WITH MELANOCORTIN-4 RECEPTOR (MC4-R) AGONIST ACTIVITY
Document Type and Number:
WIPO Patent Application WO2001074844
Kind Code:
A3
Abstract:
The present invention relates to peptides comprising the structure (S1) wherein R<1>, R<6>, R<7>, R<8>, m, n, A and B are as defined in the description and claims. Such compounds selectively activate melanocortin-4 (MC-4) receptor activity.
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Inventors:
CHEN LI
CHEUNG ADRIAN WAI-HING
CHU XIN-JIE
DANHO WALEED
SWISTOK JOSEPH
YAGALOFF KEITH ALAN
CHEUNG ADRIAN WAI-HING
CHU XIN-JIE
DANHO WALEED
SWISTOK JOSEPH
YAGALOFF KEITH ALAN
Application Number:
PCT/EP2001/003529
Publication Date:
June 13, 2002
Filing Date:
March 27, 2001
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
International Classes:
A61K38/08; A61P3/04; A61P5/00; A61P43/00; C07K1/04; A61K38/00; C07K5/107; C07K5/117; C07K7/02; C07K7/06; C07K14/68; (IPC1-7): C07K14/68; C07K5/107; A61K38/07; A61K38/34; A61P3/04
Domestic Patent References:
| WO1999064002A1 | 1999-12-16 |
Other References:
FAN W ET AL: "ROLE OF MELANOCORTINERGIC NEURONS IN FEEDING AND THE AGOUTI OBESITY SYNDROME", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 385, 9 January 1997 (1997-01-09), pages 165 - 168, XP002072475, ISSN: 0028-0836
BEDNAREK M A ET AL: "ANALOGS OF MTII, LACTAM DERIVATIVES OF ALPHA-MELANOTROPIN, MODIFIED AT THE N-TERMINUS, AND THEIR SELECTIVITY AT HUMAN MELANOCORTIN RECEPTORS 3, 4, AND 5", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 261, no. 1, 1999, pages 209 - 213, XP002159223, ISSN: 0006-291X
ADAN E.A.: "Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming brhaviour of rats", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 378, 1999, pages 249 - 258, XP002192102
BEDNAREK M A ET AL: "ANALOGS OF MTII, LACTAM DERIVATIVES OF ALPHA-MELANOTROPIN, MODIFIED AT THE N-TERMINUS, AND THEIR SELECTIVITY AT HUMAN MELANOCORTIN RECEPTORS 3, 4, AND 5", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 261, no. 1, 1999, pages 209 - 213, XP002159223, ISSN: 0006-291X
ADAN E.A.: "Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming brhaviour of rats", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 378, 1999, pages 249 - 258, XP002192102
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