Title:
SELECTIVELY ALTERING MICROBIOTA FOR IMMUNE MODULATION
Document Type and Number:
WIPO Patent Application WO/2017/211753
Kind Code:
A1
Abstract:
The invention relates to methods of modulating immune cells in a patient by altering microbiota of the patient. The invention also relates to methods of modulating treatments or therapies in a subject organism by altering microbiota of the subject. The invention also relates to cell populations, systems, arrays, cells, RNA, kits and other means for effecting this. In an example, advantageously selective targeting of a particular species in a human gut microbiota using guided nucleic acid modification is carried out to effect the alteration.
Inventors:
CLUBE JASPER (GB)
SOMMER MORTEN (DK)
GRØNDAHL CHRISTIAN (GB)
VAZQUEZ-URIBE RUBEN (DK)
VAN DER HELM ERIC (DK)
SOMMER MORTEN (DK)
GRØNDAHL CHRISTIAN (GB)
VAZQUEZ-URIBE RUBEN (DK)
VAN DER HELM ERIC (DK)
Application Number:
PCT/EP2017/063593
Publication Date:
December 14, 2017
Filing Date:
June 04, 2017
Export Citation:
Assignee:
SNIPR TECH LTD (GB)
International Classes:
A61K35/17; A61K31/7105; A61K35/15; A61P35/00; A61P37/00
Domestic Patent References:
| WO2014124226A1 | 2014-08-14 | |||
| WO2016177682A1 | 2016-11-10 |
Other References:
NOBUHIKO KAMADA ET AL: "Role of the gut microbiota in immunity and inflammatory disease", THE JOURNAL OF IMMUNOLOGY, vol. 13, no. 5, 1 May 2013 (2013-05-01), GB, pages 321 - 335, XP055402377, ISSN: 1474-1733, DOI: 10.1038/nri3430
L. V. HOOPER ET AL: "Interactions Between the Microbiota and the Immune System", SCIENCE, vol. 336, no. 6086, 8 June 2012 (2012-06-08), pages 1268 - 1273, XP055030048, ISSN: 0036-8075, DOI: 10.1126/science.1223490
JUNE L. ROUND ET AL: "The gut microbiota shapes intestinal immune responses during health and disease", THE JOURNAL OF IMMUNOLOGY, vol. 9, no. 5, 1 May 2009 (2009-05-01), GB, pages 313 - 323, XP055252815, ISSN: 1474-1733, DOI: 10.1038/nri2515
HYONGBUM KIM ET AL: "A guide to genome engineering with programmable nucleases", NATURE REVIEWS GENETICS, vol. 15, no. 5, 2 April 2014 (2014-04-02), pages 321 - 334, XP055177064, ISSN: 1471-0056, DOI: 10.1038/nrg3686
A. A. GOMAA ET AL: "Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems", MBIO, vol. 5, no. 1, 28 January 2014 (2014-01-28), pages e00928 - 13, XP055227960, DOI: 10.1128/mBio.00928-13
PAUL BG VAN ERP ET AL: "The history and market impact of CRISPR RNA-guided nucleases", CURRENT OPINION IN VIROLOGY, vol. 12, 1 June 2015 (2015-06-01), United Kingdom, pages 85 - 90, XP055402267, ISSN: 1879-6257, DOI: 10.1016/j.coviro.2015.03.011
ROBERT J CITORIK ET AL: "Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases", NATURE BIOTECHNOLOGY, GALE GROUP INC, US, vol. 32, no. 11, 1 November 2014 (2014-11-01), pages 1141 - 1145, XP002742964, ISSN: 1087-0156, [retrieved on 20140921], DOI: 10.1038/NBT.3011
L. V. HOOPER ET AL: "Interactions Between the Microbiota and the Immune System", SCIENCE, vol. 336, no. 6086, 8 June 2012 (2012-06-08), pages 1268 - 1273, XP055030048, ISSN: 0036-8075, DOI: 10.1126/science.1223490
JUNE L. ROUND ET AL: "The gut microbiota shapes intestinal immune responses during health and disease", THE JOURNAL OF IMMUNOLOGY, vol. 9, no. 5, 1 May 2009 (2009-05-01), GB, pages 313 - 323, XP055252815, ISSN: 1474-1733, DOI: 10.1038/nri2515
HYONGBUM KIM ET AL: "A guide to genome engineering with programmable nucleases", NATURE REVIEWS GENETICS, vol. 15, no. 5, 2 April 2014 (2014-04-02), pages 321 - 334, XP055177064, ISSN: 1471-0056, DOI: 10.1038/nrg3686
A. A. GOMAA ET AL: "Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems", MBIO, vol. 5, no. 1, 28 January 2014 (2014-01-28), pages e00928 - 13, XP055227960, DOI: 10.1128/mBio.00928-13
PAUL BG VAN ERP ET AL: "The history and market impact of CRISPR RNA-guided nucleases", CURRENT OPINION IN VIROLOGY, vol. 12, 1 June 2015 (2015-06-01), United Kingdom, pages 85 - 90, XP055402267, ISSN: 1879-6257, DOI: 10.1016/j.coviro.2015.03.011
ROBERT J CITORIK ET AL: "Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases", NATURE BIOTECHNOLOGY, GALE GROUP INC, US, vol. 32, no. 11, 1 November 2014 (2014-11-01), pages 1141 - 1145, XP002742964, ISSN: 1087-0156, [retrieved on 20140921], DOI: 10.1038/NBT.3011
Attorney, Agent or Firm:
CLUBE, Jasper (GB)
Download PDF:
Previous Patent: AXIAL TRANSMISSION ARRANGEMENT FOR A PARALLEL HYBRID DEVICE
Next Patent: COOLABLE ULTRASOUND PROBE
Next Patent: COOLABLE ULTRASOUND PROBE