Title:
SELF-ADHESIVE HEMOSTATIC REPAIR GEL WITH MULTI-SCALE PORE NETWORK, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/087678
Kind Code:
A1
Abstract:
The present invention relates to a self-adhesive hemostatic repair gel with a multi-scale pore network, and a preparation method therefor and the use thereof. The hemostatic repair gel comprises component A and component B. The component A is a hydrogel matrix layer of a composite multi-scale pore network formed by means of mixing a microporous hydrogel preparation solution and a nanoporous hydrogel preparation solution. The component B is a bioadhesive active molecule aqueous solution capable of bridging a gel matrix and a tissue interface. For the self-adhesive hemostatic repair gel, the introduction of nanoporous hydrogel with an island-like distribution into the hydrogel with a microporous network can reduce the rigidity of the gel matrix, improve the conformal contact between the gel matrix and soft tissue, accelerate the combination (a hydrogen bond, an ionic bond and a covalent bond) with the surface of the soft tissue, and promote energy dissipation at a pressure interface. Moreover, a bioadhesive active molecule can achieve the bridging of the nanoporous hydrogel and a soft tissue interface. The instant and firm adhesion of the gel and the soft tissue interface is realized under the combined action of the nanoporous hydrogel and a bridging adhesive polymer, so that rapid hemostatic sealing and repairing of wounds are realized.
Inventors:
ZHU CHUHONG (CN)
LI YINGHAO (CN)
TAN JU (CN)
QIN ZHONGLIANG (CN)
LI YINGHAO (CN)
TAN JU (CN)
QIN ZHONGLIANG (CN)
Application Number:
PCT/CN2023/101984
Publication Date:
May 02, 2024
Filing Date:
June 21, 2023
Export Citation:
Assignee:
UNIV ARMY MEDICAL (CN)
International Classes:
C08J9/36; A61L15/24; A61L15/26; A61L15/28; A61L15/32; A61L15/42; A61L15/62; A61L24/00; A61L24/04; A61L24/06; A61L24/08; A61L24/10; C08J9/00; C08L5/04; C08L5/08; C08L33/02; C08L33/24; C08L33/26; C08L77/04; C08L83/04; C08L89/00
Foreign References:
| CN115746388A | 2023-03-07 | |||
| CN109675092A | 2019-04-26 | |||
| CN113637186A | 2021-11-12 | |||
| CN110240712A | 2019-09-17 | |||
| US20190091367A1 | 2019-03-28 |
Attorney, Agent or Firm:
BEIJING EASY JOY SOON IP AGENT LTD (CN)
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