Title:
SEMI-SYNTHESIS OF TAXANE INTERMEDIATES FROM 9-DIHYDRO-13-ACETYLBACCATIN III
Document Type and Number:
WIPO Patent Application WO2005044811
Kind Code:
A3
Abstract:
A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.
Inventors:
NAIDU RAGINA (CA)
Application Number:
PCT/US2004/035583
Publication Date:
September 29, 2005
Filing Date:
October 27, 2004
Export Citation:
Assignee:
PHYTOGEN LIFE SCIENCES INC (CA)
PHYTOGEN INC (US)
NAIDU RAGINA (CA)
PHYTOGEN INC (US)
NAIDU RAGINA (CA)
International Classes:
C07D305/14; (IPC1-7): C07D305/14
Foreign References:
| US20030054977A1 | 2003-03-20 |
Other References:
A. NIKOLAKAKIS ET AL.: "Taxus canadensis Abundant Taxane: Conversion to Paclitaxel and Rearrangements", BIOORG. MED. CHEM., vol. 8, no. 6, 2000, pages 1269 - 1280, XP002330171
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