SENESCENT T CELL-TARGETING VACCINE FOR PREVENTING OR TREATING ABNORMAL SUGAR METABOLISM

WIPO Patent Application WO/2020/096046

A1

Provided is a vaccine for preventing or treating abnormal sugar metabolism, said vaccine comprising any of (1) to (3): (1) a polypeptide containing the amino acid sequence represented by SEQ ID NO: 2 or a nonhuman mammal-derived amino acid sequence corresponding to SEQ ID NO: 2; (2) a polypeptide containing an amino acid sequence which is derived from the amino acid sequence represented by SEQ ID NO: 2 or from a nonhuman mammal-derived amino acid sequence corresponding to SEQ ID NO: 2 by substitution, deletion, insertion or addition of one to several amino acid residues; and (3) an expression vector capable of expressing the aforesaid polypeptide (1) or (2).

NAKAGAMI HIRONORI (JP)
YOSHIDA SHOTA (JP)

PCT/JP2019/043886

May 14, 2020

November 08, 2019

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UNIV OSAKA (JP)

A61K39/00; A61K39/39; A61K39/395; A61P3/04; A61P3/08; A61P3/10; A61P9/10; A61P13/12; A61P25/00; C07K7/06; C07K16/28; C12N15/117; C12N15/12

JP2015522252A	2015-08-06
JP2005503319A	2005-02-03

CHAKRABARTY, S. ET AL.: "2-H-W15-7-O/P: Blockade of CD30/CD30L interactions does not facilitate autoimmune diabetes in NOD mice", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 31, 2001, pages 208, XP009520988, ISSN: 0919-1984
SHIRAKAWA, K. ET AL: "Obesity accelerates T cell senescence in murine visceral adipose tissue", JOURNAL OF CLINICAL INVESTIGATION, vol. 126, no. 12, 1 December 2016 (2016-12-01), pages 4626 - 4639, XP055704747, ISSN: 0021-9738, DOI: 10.1172/JCI88606

TAKASHIMA, Hajime (JP)

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