Title:
SENOLYSIS BY AMMONIA-LOWERING COMPONENT
Document Type and Number:
WIPO Patent Application WO/2023/182475
Kind Code:
A1
Abstract:
The present invention addresses the problem of developing a method that can more conveniently remove senescent cells within an organism while having few side effects. The present inventors focused on the mechanism by which ammonia, which has been metabolically produced in excess, maintains the survival of the senescent cell, and demonstrated that senolysis is made possible by enhancing ammonia excretion. More specifically, it was demonstrated in animal experiments with mice that the expression level of p21, a senescent cell marker, is significantly lowered when an ammonia-excretion component is administered to aged mice. It has been shown for the first time that a senolytic effect is exhibited by the intake of a component that removes ammonia.
Inventors:
KAMIMOTO TAKAHASHI SHOKO (JP)
SAITO KENJI (JP)
SAITO KENJI (JP)
Application Number:
PCT/JP2023/011704
Publication Date:
September 28, 2023
Filing Date:
March 24, 2023
Export Citation:
Assignee:
TAZ INC (JP)
International Classes:
A61K45/00; A23L33/10; A23L33/17; A61K31/19; A61K31/198; A61K31/7016; A61P43/00
Other References:
JOHMURA YOSHIKAZU, YAMANAKA TAKEHIRO, OMORI SATOTAKA, WANG TEH-WEI, SUGIURA YUKI, MATSUMOTO MASAKI, SUZUKI NARUMI, KUMAMOTO SOICHI: "Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 371, no. 6526, 15 January 2021 (2021-01-15), US , pages 265 - 270, XP093095033, ISSN: 0036-8075, DOI: 10.1126/science.abb5916
ANONYMOUS: "Wakasa's secret top - Citrulline", 25 April 2018 (2018-04-25), XP093095036, Retrieved from the Internet [retrieved on 20231025]
ANONYMOUS: "Wakasa's secret top - Taurine", 2 May 2014 (2014-05-02), XP093095040, Retrieved from the Internet
ADACHI TAKUYA, SHINICHI FUJIOKA , YASUYUKI SHIMOMURA , MARI KAWAKAMI , TOSHIYA OSAWA , TATSUYA ITOSHIMA: "Examination of the utility of the carnitine replacement therapy for hyperammonemia", KANZO, vol. 55, no. 8, 1 January 2014 (2014-01-01), pages 459 - 467, XP093095044, DOI: 10.2957/kanzo.55.459
ANONYMOUS: "ARGI-U Combination Granules", PACKAGE INSERT, EA PHARMA CO., LTD., JP, 30 November 2015 (2015-11-30), JP, pages 1 - 2, XP009550012
ANONYMOUS: "Carbaglu 200 mg dispersible tablets (carglumic acid) - package insert", 1 April 2019 (2019-04-01), XP093095048, Retrieved from the Internet [retrieved on 20231025]
ANONYMOUS: "Portolac", PACKAGE INSERT, NIPPON SHINYAKU CO., LTD., JP, 1 May 2021 (2021-05-01), JP, pages 1 - 2, XP009550034
ANONYMOUS: "Buphenyl Tablets 500mg/Buphenyl Granules 94%. ", PACKAGE INSERT, ORPHANPACIFIC, INC., JP, 1 May 2015 (2015-05-01), JP, pages 1 - 44, XP009550007
ANONYMOUS: "Rifxima tablets 200 mg. Package insert", PACKAGE INSERT, ASKA PHARMACEUTICAL CO., LTD., JP, 30 November 2018 (2018-11-30), JP, XP009550035
ANONYMOUS: "Ornithine", 5 February 2015 (2015-02-05), XP093095052, Retrieved from the Internet
MATSUNAGA, AYAKO: "Inborn errors of metabolism that cause adult-onset hyperammonemia", JOURNAL OF THE JAPANESE SOCIETY OF INTENSIVE CARE MEDICINE, vol. 29, no. 2, 28 February 2022 (2022-02-28), pages 105 - 106, XP009549504, ISSN: 1340-7988, DOI: 10.3918/jsicm.29_105
ANONYMOUS: "Lactulose syrup 60% "Kowa" 10ml/Lactulose syrup 60%"Kowa" 15ml.", PACKAGE INSERT, KOWA CO., JP, 30 November 2019 (2019-11-30), JP, XP009550036
SAKAI, SHIGEO: "Functional food and health maintenance", SHOKUHIN TO KAGAKU - FOOD SCIENCE, SHOKUHIN TO KAGAKUSHA, OSAKA, JP, vol. 50, no. 5, 30 November 2007 (2007-11-30), JP , pages 78 - 86, XP009549387, ISSN: 0037-4105
ANONYMOUS: "Stay healthy during the rainy season with the power of traditional food “Umeboshi” ", ISDG ISHOKUDOGEN.COM, 2 June 2021 (2021-06-02), XP093095057, Retrieved from the Internet [retrieved on 20231025]
ANONYMOUS: "Knowledge of milk that is useful on the sales floor", CENTRAL DAIRY COUNCIL, JAPAN DAIRY INDUSTRY ASSOCIATION, JP, vol. 8, 30 November 2006 (2006-11-30), JP, pages 1 - 14, XP009550037
ANONYMOUS: "Amino acid shampoo is recommended for hair and scalp. ([Sodium benzoate] Preservative component contained in bamboo leaves)", 25 July 2020 (2020-07-25), XP093095065, Retrieved from the Internet
ANONYMOUS: "Lactulose", MORINAGA MILK INDUSTRY CO., LTD., 16 March 2022 (2022-03-16), XP093095068, Retrieved from the Internet
ANONYMOUS: "Wakasa's secret top - Citrulline", 25 April 2018 (2018-04-25), XP093095036, Retrieved from the Internet
ANONYMOUS: "Wakasa's secret top - Taurine", 2 May 2014 (2014-05-02), XP093095040, Retrieved from the Internet
ADACHI TAKUYA, SHINICHI FUJIOKA , YASUYUKI SHIMOMURA , MARI KAWAKAMI , TOSHIYA OSAWA , TATSUYA ITOSHIMA: "Examination of the utility of the carnitine replacement therapy for hyperammonemia", KANZO, vol. 55, no. 8, 1 January 2014 (2014-01-01), pages 459 - 467, XP093095044, DOI: 10.2957/kanzo.55.459
ANONYMOUS: "ARGI-U Combination Granules", PACKAGE INSERT, EA PHARMA CO., LTD., JP, 30 November 2015 (2015-11-30), JP, pages 1 - 2, XP009550012
ANONYMOUS: "Carbaglu 200 mg dispersible tablets (carglumic acid) - package insert", 1 April 2019 (2019-04-01), XP093095048, Retrieved from the Internet
ANONYMOUS: "Portolac", PACKAGE INSERT, NIPPON SHINYAKU CO., LTD., JP, 1 May 2021 (2021-05-01), JP, pages 1 - 2, XP009550034
ANONYMOUS: "Buphenyl Tablets 500mg/Buphenyl Granules 94%. ", PACKAGE INSERT, ORPHANPACIFIC, INC., JP, 1 May 2015 (2015-05-01), JP, pages 1 - 44, XP009550007
ANONYMOUS: "Rifxima tablets 200 mg. Package insert", PACKAGE INSERT, ASKA PHARMACEUTICAL CO., LTD., JP, 30 November 2018 (2018-11-30), JP, XP009550035
ANONYMOUS: "Ornithine", 5 February 2015 (2015-02-05), XP093095052, Retrieved from the Internet
MATSUNAGA, AYAKO: "Inborn errors of metabolism that cause adult-onset hyperammonemia", JOURNAL OF THE JAPANESE SOCIETY OF INTENSIVE CARE MEDICINE, vol. 29, no. 2, 28 February 2022 (2022-02-28), pages 105 - 106, XP009549504, ISSN: 1340-7988, DOI: 10.3918/jsicm.29_105
ANONYMOUS: "Lactulose syrup 60% "Kowa" 10ml/Lactulose syrup 60%"Kowa" 15ml.", PACKAGE INSERT, KOWA CO., JP, 30 November 2019 (2019-11-30), JP, XP009550036
SAKAI, SHIGEO: "Functional food and health maintenance", SHOKUHIN TO KAGAKU - FOOD SCIENCE, SHOKUHIN TO KAGAKUSHA, OSAKA, JP, vol. 50, no. 5, 30 November 2007 (2007-11-30), JP , pages 78 - 86, XP009549387, ISSN: 0037-4105
ANONYMOUS: "Stay healthy during the rainy season with the power of traditional food “Umeboshi” ", ISDG ISHOKUDOGEN.COM, 2 June 2021 (2021-06-02), XP093095057, Retrieved from the Internet
ANONYMOUS: "Knowledge of milk that is useful on the sales floor", CENTRAL DAIRY COUNCIL, JAPAN DAIRY INDUSTRY ASSOCIATION, JP, vol. 8, 30 November 2006 (2006-11-30), JP, pages 1 - 14, XP009550037
ANONYMOUS: "Amino acid shampoo is recommended for hair and scalp. ([Sodium benzoate] Preservative component contained in bamboo leaves)", 25 July 2020 (2020-07-25), XP093095065, Retrieved from the Internet
ANONYMOUS: "Lactulose", MORINAGA MILK INDUSTRY CO., LTD., 16 March 2022 (2022-03-16), XP093095068, Retrieved from the Internet
Attorney, Agent or Firm:
UCHIYAMA Tsutomu et al. (JP)
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