Title:
SENSITIZING CELLS TO COMPOUNDS USING LIPID-MEDIATED GENE AND COMPOUND DELIVERY
Document Type and Number:
WIPO Patent Application WO1999039740
Kind Code:
A3
Abstract:
The present invention relates to methods and compositions for sensitizing a cell to a compound such as a prodrug.
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Inventors:
MACLACHLAN IAN (CA)
GRAHAM ROGER W (CA)
BUCHKOWSKY SUSAN S (CA)
GRAHAM ROGER W (CA)
BUCHKOWSKY SUSAN S (CA)
Application Number:
PCT/CA1999/000089
Publication Date:
October 28, 1999
Filing Date:
February 03, 1999
Export Citation:
Assignee:
INEX PHARMACEUTICALS CORP (CA)
MACLACHLAN IAN (CA)
GRAHAM ROGER W (CA)
BUCHKOWSKY SUSAN S (CA)
MACLACHLAN IAN (CA)
GRAHAM ROGER W (CA)
BUCHKOWSKY SUSAN S (CA)
International Classes:
A61K9/14; A61K31/711; A61K38/20; A61K38/45; A61K38/51; A61K45/00; A61K47/44; A61K48/00; A61P35/00; C12N15/88; (IPC1-7): A61K48/00
Domestic Patent References:
| WO1996039831A1 | 1996-12-19 | |||
| WO1995005835A1 | 1995-03-02 |
Other References:
RUBAS W ET AL: "TREATMENT OF MURINE L1210 LYMPHOID LEUKEMIA AND MELANOMA B16 WITH LIPOPHILIC CYTOSINE ARABINOSIDE PRODRUGS INCORPORATED INTO UNILAMELLAR LIPOSOMES", INTERNATIONAL JOURNAL OF CANCER, vol. 37, 1 January 1986 (1986-01-01), pages 149 - 154, XP000653319, ISSN: 0020-7136
MOOLTEN: "TUMOR CHEMOSENSITIVITY CONFERRED BY INSERTED HERPES THYMIDINE KINASE GENES: PARADIGM FOR A PROSPECTIVE CANCER CONTROL STUDY", CANCER RESEARCH, vol. 46, 1986, pages 5276 - 5281, XP000610741
DATABASE MEDLINE [online] BALZARINI ET AL: "SUPERIOR CYTOSTATIC ACTIVITY OF THE GANCICLOVIR ELAIDIC ACID ESTER DUE TO THE PROLONGED INTRACELLULAR RETENTION OF GANCICLOVIR ANABOLITES IN HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE GENE-TRANSFECTED TUMOR CELLS", XP002110790, retrieved from STN Database accession no. 1998276748
MOOLTEN: "TUMOR CHEMOSENSITIVITY CONFERRED BY INSERTED HERPES THYMIDINE KINASE GENES: PARADIGM FOR A PROSPECTIVE CANCER CONTROL STUDY", CANCER RESEARCH, vol. 46, 1986, pages 5276 - 5281, XP000610741
DATABASE MEDLINE [online] BALZARINI ET AL: "SUPERIOR CYTOSTATIC ACTIVITY OF THE GANCICLOVIR ELAIDIC ACID ESTER DUE TO THE PROLONGED INTRACELLULAR RETENTION OF GANCICLOVIR ANABOLITES IN HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE GENE-TRANSFECTED TUMOR CELLS", XP002110790, retrieved from STN Database accession no. 1998276748
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