SEQUENCE OF ACTIVATED PROTEIN C

WIPO Patent Application WO/2023/171719

A1

The purpose of the present invention is to provide a breakthrough activated protein C that can cure protein C deficiency, a pharmaceutical composition containing the same, etc. The present invention provides a polypeptide, which contains an amino acid sequence represented by formula (I): A1-A2-A3 (wherein: A1 represents an amino acid sequence containing the amino acid sequence of the light chain of protein C or a homologue thereof; A2 represents an amino acid sequence constituting a self-cleavage site; and A3 represents an amino acid sequence containing the amino acid sequence of the heavy chain of protein C or a homologue thereof) or a partial polypeptide thereof, wherein the dimeric protein consisting of the N-terminal fragment and the C-terminal fragment of the cleavage site of A2 or a partial protein thereof has protein C activity. This polypeptide or a partial polypeptide thereof enables: 1) the production of the activated protein C in the form of a recombinant preparation; and 2) the use thereof in effective gene therapy for protein C deficiency.

WO/2019/142773	PRODUCTION METHOD FOR PROTEASE OF M23A FAMILY
JP2002522081	[Title of Invention] Proteases and related proteins
JPH03290191	MANIFESTATION PLASMID AND ITS USE

OHMORI TSUKASA (JP)
TOGASHI TOMOKI (JP)
HAYAKAWA MORISADA (JP)
KAMOSHITA NOBUHIKO (JP)
KASHIWAKURA YUJI (JP)
HIRAMOTO TAKAFUMI (JP)
BAATARTSOGT NEMEKHBAYAR (JP)

PCT/JP2023/008880

September 14, 2023

March 08, 2023

Click for automatic bibliography generation  

UNIV JICHI MEDICAL (JP)

C12N15/57; A61K35/76; A61K38/36; A61K48/00; A61P7/02; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/64; C12N15/864

WO2001070763A1	2001-09-27
WO2000066754A1	2000-11-09

JP2000501928A	2000-02-22
JPH022372A	1990-01-08
JP2016518840A	2016-06-30

KAMADA, Mitsunori et al. (JP)

View/Download PDF      PDF Help

Previous Patent: ANTENNA AND DISPLAY DEVICE

Next Patent: TRANSMISSION CIRCUIT