Title:
SEQUENTIAL DRUG DELIVERY MATERIAL COMPRISING BMP-2 AND ALENDRONATE, METHOD FOR PRODUCING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/225141
Kind Code:
A1
Abstract:
The present invention relates to a sequential drug delivery material comprising BMP-2 and alendronate, a method for preparing same, and a use thereof for bone regeneration. The multi-drug delivery material according to the present invention uses BMP-2 at a significantly lower concentration than the prior art, and thus can minimize the side effects of BMP-2. Moreover, the multi-drug delivery material can induce a significantly improved bone regeneration effect by suppressing the side effects of BMP-2, that is, bone resorption caused by osteoclast differentiation, through sequential discharge with alendronate, and thus can maximize drug efficacy, and is therefore expected to be useful for bone regeneration for treating bone diseases having various causes.
Inventors:
YOON DAE SUNG (KR)
LEE DONGTAK (KR)
KIM INSU (KR)
JUNG HYO GI (KR)
LEE GYUDO (KR)
JEON OKHEE (KR)
CHANG HAK (KR)
WUFUER MAIERDANJIANG (KR)
KIM BYUNG JUN (KR)
JANG JAE WON (KR)
KIM HYUNJI (KR)
LEE DONGTAK (KR)
KIM INSU (KR)
JUNG HYO GI (KR)
LEE GYUDO (KR)
JEON OKHEE (KR)
CHANG HAK (KR)
WUFUER MAIERDANJIANG (KR)
KIM BYUNG JUN (KR)
JANG JAE WON (KR)
KIM HYUNJI (KR)
Application Number:
PCT/KR2022/000530
Publication Date:
October 27, 2022
Filing Date:
January 12, 2022
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K47/42; A61K9/16; A61K31/663; A61K38/18; A61K47/02; A61L27/22; A61L27/40; A61L27/54; A61L27/56; A61P19/08
Domestic Patent References:
| WO2010024549A2 | 2010-03-04 |
Foreign References:
| KR20180046386A | 2018-05-08 |
Other References:
CHO TAE HYUNG, KIM IN SOOK, LEE BEOMSEOK, PARK SI-NAE, KO JAE-HYUNG, HWANG SOON JUNG: "Early and Marked Enhancement of New Bone Quality by Alendronate-Loaded Collagen Sponge Combined with Bone Morphogenetic Protein-2 at High Dose: A Long-Term Study in Calvarial Defects in a Rat Model", TISSUE ENGINEERING PART A, MARY ANN LIEBERT, US, vol. 23, no. 23-24, 1 December 2017 (2017-12-01), US , pages 1343 - 1360, XP055978856, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2016.0557
CHO TAE HYUNG, KIM IN SOOK, LEE BEOMSEOK, PARK SI-NAE, KO JAE-HYUNG, HWANG SOON JUNG: "Early and Marked Enhancement of New Bone Quality by Alendronate-Loaded Collagen Sponge Combined with Bone Morphogenetic Protein-2 at High Dose: A Long-Term Study in Calvarial Defects in a Rat Model", TISSUE ENGINEERING PART A, MARY ANN LIEBERT, US, vol. 23, no. 23-24, 1 December 2017 (2017-12-01), US , pages 1343 - 1360, XP055978856, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2016.0557
LEE DONGTAK, WUFUER MAIERDANJIANG, KIM INSU, CHOI TAE HYUN, KIM BYUNG JUN, JUNG HYO GI, JEON BYOUNGJUN, LEE GYUDO, JEON OK HEE, CH: "Sequential dual-drug delivery of BMP-2 and alendronate from hydroxyapatite-collagen scaffolds for enhanced bone regeneration", SCIENTIFIC REPORTS, vol. 11, no. 1, 1 December 2021 (2021-12-01), XP055978870, DOI: 10.1038/s41598-020-80608-3
CHO TAE HYUNG, KIM IN SOOK, LEE BEOMSEOK, PARK SI-NAE, KO JAE-HYUNG, HWANG SOON JUNG: "Early and Marked Enhancement of New Bone Quality by Alendronate-Loaded Collagen Sponge Combined with Bone Morphogenetic Protein-2 at High Dose: A Long-Term Study in Calvarial Defects in a Rat Model", TISSUE ENGINEERING PART A, MARY ANN LIEBERT, US, vol. 23, no. 23-24, 1 December 2017 (2017-12-01), US , pages 1343 - 1360, XP055978856, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2016.0557
LEE DONGTAK, WUFUER MAIERDANJIANG, KIM INSU, CHOI TAE HYUN, KIM BYUNG JUN, JUNG HYO GI, JEON BYOUNGJUN, LEE GYUDO, JEON OK HEE, CH: "Sequential dual-drug delivery of BMP-2 and alendronate from hydroxyapatite-collagen scaffolds for enhanced bone regeneration", SCIENTIFIC REPORTS, vol. 11, no. 1, 1 December 2021 (2021-12-01), XP055978870, DOI: 10.1038/s41598-020-80608-3
Attorney, Agent or Firm:
DAHAI INTERNATIONAL PATENT & LAW FIRM (KR)
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