Title:
SERINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1997/005107
Kind Code:
A1
Abstract:
Compounds represented by general formula (I) (wherein n is 1 or 2; R1 represents optionally carboxylated C1-10 alkyl, optionally substituted C6-10 aryl, etc.; and R2 represents hydrogen, C1-10 alkyl, optionally substituted C7-12 aralkyl, etc.), for example, trans-4-amino[(S)-N-[(R)-2-propoxycarbonylamino-3-(1',1'-dimethylpropoxy)propanoyl]prolyl]aminomethylcyclohexane. Because of having a potent inhibitory activity on thrombin, these compounds are useful as an anticoagulant.
Inventors:
OSHIMA MASAHIRO (JP)
IWASE NORIMICHI (JP)
SUGAWARA KOICHI (JP)
OKITSU MISAO (JP)
IWASE NORIMICHI (JP)
SUGAWARA KOICHI (JP)
OKITSU MISAO (JP)
Application Number:
PCT/JP1996/002026
Publication Date:
February 13, 1997
Filing Date:
July 19, 1996
Export Citation:
Assignee:
MITSUBISHI CHEM CORP (JP)
OSHIMA MASAHIRO (JP)
IWASE NORIMICHI (JP)
SUGAWARA KOICHI (JP)
OKITSU MISAO (JP)
OSHIMA MASAHIRO (JP)
IWASE NORIMICHI (JP)
SUGAWARA KOICHI (JP)
OKITSU MISAO (JP)
International Classes:
C07K5/06; A61K38/00; (IPC1-7): C07D207/16; A61K31/40; A61K31/445; C07D211/60
Domestic Patent References:
| WO1996003374A1 | 1996-02-08 |
Foreign References:
| JPH07252217A | 1995-10-03 |
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