Title:
SERUM ALBUMIN SCAFFOLD-BASED PROTEINS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2004101620
Kind Code:
A3
Abstract:
Disclosed herein are libraries of candidate binding proteins derived from a serum albumin scaffold, from which useful binding proteins may be selected that are specific for known and unknown targets. Also disclosed herein are methods for selection of serum albumin scaffold-based candidate binding proteins which possess such desired binding characteristics.
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Inventors:
LIPOVSEK DASA (US)
SUN LIN (US)
KOVTUN ALEXANDER V (US)
SUN LIN (US)
KOVTUN ALEXANDER V (US)
Application Number:
PCT/US2004/013726
Publication Date:
March 31, 2005
Filing Date:
May 03, 2004
Export Citation:
Assignee:
COMPOUND THERAPEUTICS INC (US)
LIPOVSEK DASA (US)
SUN LIN (US)
KOVTUN ALEXANDER V (US)
LIPOVSEK DASA (US)
SUN LIN (US)
KOVTUN ALEXANDER V (US)
International Classes:
C07K14/765; (IPC1-7): C07K14/765; C12N15/10
Domestic Patent References:
| WO1998031700A1 | 1998-07-23 | |||
| WO1999013914A1 | 1999-03-25 | |||
| WO2000060070A1 | 2000-10-12 |
Other References:
SUGIO S ET AL: "Crystal structure of human serum albumin at 2.5 angstroms resolution", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 12, no. 6, 1999, pages 439 - 446, XP002964157, ISSN: 0269-2139
ELY K ET AL: "Common molecular scaffold for two unrelated RGD molecules", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 8, no. 8, August 1995 (1995-08-01), pages 823 - 827, XP002088954, ISSN: 0269-2139
SKERRA A: "'ANTICALINS': A NEW CLASS OF ENGINEERED LIGNAD-BINDING PROTEINS WITH ANTIBODY-LIKE PROPERTIES", REVIEWS IN MOLECULAR BIOTECHNOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 74, no. 4, June 2001 (2001-06-01), pages 257 - 275, XP001079016, ISSN: 1389-0352
BHATTACHARYA ANANYO A ET AL: "Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 49, 8 December 2000 (2000-12-08), pages 38731 - 38738, XP002310833, ISSN: 0021-9258
XIAO MIN HE ET AL: "ATOMIC STRUCTURE AND CHEMISTRY OF HUMAN SERUM ALBUMIN", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 358, 16 July 1992 (1992-07-16), pages 209 - 215, XP001146474, ISSN: 0028-0836
CURRY STEPHEN ET AL: "Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites", NATURE STRUCTURAL BIOLOGY, vol. 5, no. 9, September 1998 (1998-09-01), pages 827 - 835, XP002310834, ISSN: 1072-8368
KOVTUN A, ET AL.: "ISOLATION OF FUNCTIONAL INHIBITORS TO HUMAN VEGF BY IN VITRO SELECTION USING PROFUSION", INTERNATIONAL SYMPOSIUM ON SIGNAL TRANSUCTION MODULATORS, XX, XX, 23 October 2003 (2003-10-23), XX, pages 01, XP008040256
ELY K ET AL: "Common molecular scaffold for two unrelated RGD molecules", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 8, no. 8, August 1995 (1995-08-01), pages 823 - 827, XP002088954, ISSN: 0269-2139
SKERRA A: "'ANTICALINS': A NEW CLASS OF ENGINEERED LIGNAD-BINDING PROTEINS WITH ANTIBODY-LIKE PROPERTIES", REVIEWS IN MOLECULAR BIOTECHNOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 74, no. 4, June 2001 (2001-06-01), pages 257 - 275, XP001079016, ISSN: 1389-0352
BHATTACHARYA ANANYO A ET AL: "Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 49, 8 December 2000 (2000-12-08), pages 38731 - 38738, XP002310833, ISSN: 0021-9258
XIAO MIN HE ET AL: "ATOMIC STRUCTURE AND CHEMISTRY OF HUMAN SERUM ALBUMIN", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 358, 16 July 1992 (1992-07-16), pages 209 - 215, XP001146474, ISSN: 0028-0836
CURRY STEPHEN ET AL: "Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites", NATURE STRUCTURAL BIOLOGY, vol. 5, no. 9, September 1998 (1998-09-01), pages 827 - 835, XP002310834, ISSN: 1072-8368
KOVTUN A, ET AL.: "ISOLATION OF FUNCTIONAL INHIBITORS TO HUMAN VEGF BY IN VITRO SELECTION USING PROFUSION", INTERNATIONAL SYMPOSIUM ON SIGNAL TRANSUCTION MODULATORS, XX, XX, 23 October 2003 (2003-10-23), XX, pages 01, XP008040256
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