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Title:
SERUM CALCIUM DEPRESSING FACTOR
Document Type and Number:
WIPO Patent Application WO/1992/015615
Kind Code:
A1
Abstract:
A novel serum calcium depressing factor derived from swine pancreas, which has a molecular weight of 26,500 to 28,000 D as determined by polyacrylamide gel electrophoresis, an isoelectric point of about 4.5 as determined by isoelectric electrophoresis, and an amino acid sequence of Val-Val-Gly-Gly-Gln-Asn-Ala-Ile-Pro-His-Ser-Trp-Pro-Trp-Gln-Ile-Arg-Leu- at or near the N-terminus. It has a protease activity and is inhibited by PMSF, chymostatin and trypsin inhibitor but not by APMSF and E-64. The novel depressing factor is expected to be applicable as a medicine for treating and preventing bone diseases such as osteoporosis.

Inventors:
TOMOMURA AKITO (JP)
SAHEKI TAKEYORI (JP)
TAKAOKA YOSHITO (JP)
Application Number:
PCT/JP1992/000251
Publication Date:
September 17, 1992
Filing Date:
March 03, 1992
Export Citation:
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Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K38/00; A61K38/46; A61P3/02; A61P3/14; A61P19/10; A61P43/00; C07K1/20; C07K14/435; C12N9/64; (IPC1-7): A61K35/39; A61K37/02; C07K3/02; C07K15/06; C07K15/12
Foreign References:
Other References:
Proc. Natl. Acad. Sci. USA, Vol. 86, No. 15 (1989), NISHI-M- et al., "Conservation of the Sequence of Islet Amyloid Polypeptide in Five Mammals is Consistent with its Putative Role as an Islet Hormone", p. 5738-5742.
"Term Calcitonin Biochemical Dictionary", April 10, 1984 (10.04.84), Tokyo Kagaku Dojin (Tokyo), p. 276-277.
See also references of EP 0641858A4
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