SHORT INTERFERING NUCLEIC ACID (SINA) MOLECULES FOR TARGETING β-CATENIN AND USES THEREOF

WIPO Patent Application WO/2023/122317

A3

The present invention is in the field of pharmaceutical compounds and preparations and method of their use in the treatment of disease. Described are short interfering nucleic acid (siNA) molecules comprising modified nucleotides that target β-catenin, compositions containing the same, and uses thereof for treating or preventing diseases. In particular, the present invention is in the field of siNA molecules that targets β-catenin for treatment of cancer.

BEIGELMAN LEONID (US)
ELTEPU LAXMAN (US)
HONG JIN (US)
BHATTACHARYA ANEERBAN (US)
MONTERO SAUL MARTINEZ (US)
HUANG VERA (US)

PCT/US2022/053896

August 03, 2023

December 22, 2022

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ALIGOS THERAPEUTICS INC (US)

C12N15/113

WO2017173297A1	2017-10-05
WO2014065849A1	2014-05-01
WO2012018754A2	2012-02-09
WO2021252557A1	2021-12-16
WO2019079472A1	2019-04-25
WO2021178885A1	2021-09-10
WO2023003995A1	2023-01-26

ANDERSON BROOKE A ET AL: "Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides", NUCLEIC ACIDS RESEARCH, vol. 49, no. 16, 20 August 2021 (2021-08-20), GB, pages 9026 - 9041, XP093036509, ISSN: 0305-1048, Retrieved from the Internet DOI: 10.1093/nar/gkab718
YU FANYUAN ET AL: "Wnt/[beta]-catenin signaling in cancers and targeted therapies", SIGNAL TRANSDUCTION AND TARGETED THERAPY, vol. 6, no. 1, 30 August 2021 (2021-08-30), XP055863867, Retrieved from the Internet DOI: 10.1038/s41392-021-00701-5

SCHORR, Kristel et al. (US)

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