Title:
SHP2 INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/011513
Kind Code:
A1
Abstract:
A following compound or a pharmaceutically acceptable salt, ester, optical isomer, stereoisomer, polymorph, solvate, N-oxide, isotope labeled-compound, metabolite, chelate, complex, clathrate, or prodrug thereof, and a pharmaceutical composition comprising the compound. Further provided is an application of a compound in preparation of a drug for an SHP2 phosphatase-related disease. Further provided is a treatment method for an SHP2 phosphatase-related disease.
Inventors:
LI WENMING (CN)
LI XIAOBO (CN)
PIAO MINGNAN (CN)
LU PENG (CN)
WANG NING (CN)
YU GUOKUN (CN)
LIU JUNRONG (CN)
ZHANG YU (CN)
YU TIANTIAN (CN)
LI XIAOBO (CN)
PIAO MINGNAN (CN)
LU PENG (CN)
WANG NING (CN)
YU GUOKUN (CN)
LIU JUNRONG (CN)
ZHANG YU (CN)
YU TIANTIAN (CN)
Application Number:
PCT/CN2022/109904
Publication Date:
February 09, 2023
Filing Date:
August 03, 2022
Export Citation:
Assignee:
BEIJING TIDE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07J43/00; A61K31/495; A61P35/00
Domestic Patent References:
| WO2020172655A1 | 2020-08-27 | |||
| WO2009027395A1 | 2009-03-05 |
Foreign References:
| CN104211661A | 2014-12-17 |
Other References:
WU XIAOQIN, XU GANG, LI XIAOBO, XU WEIREN, LI QIANJIN, LIU WEI, KIRBY KAREN A., LOH MIGNON L., LI JUN, SARAFIANOS STEFAN G., QU CH: "Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 3, 14 February 2019 (2019-02-14), US , pages 1125 - 1137, XP093031467, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b00513
SUN LIANG-PENG, GAO LI-XIN, MA WEI-PING, NAN FA-JUN, LI JIA, PIAO HU-RI: "Synthesis and Biological Evaluation of 2,4,6-Trihydroxychalcone Derivatives as Novel Protein Tyrosine Phosphatase 1B Inhibitors : ", CHEMICAL BIOLOGY & DRUG DESIGN, BLACKWELL MUNKSGAARD, vol. 80, no. 4, 1 October 2012 (2012-10-01), pages 584 - 590, XP093031470, ISSN: 1747-0277, DOI: 10.1111/j.1747-0285.2012.01431.x
LIU, X. GO, M.L.: "Antiproliferative activity of chalcones with basic functionalities", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 15, no. 22, 26 September 2007 (2007-09-26), AMSTERDAM, NL, pages 7021 - 7034, XP022273627, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2007.07.042
LIU, X.L. TEE, H.W. GO, M.L.: "Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 16, no. 1, 1 January 2008 (2008-01-01), AMSTERDAM, NL, pages 171 - 180, XP022485938, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2007.10.006
K. S. GROSSMAN ET AL., ADV. CANCER RES, vol. 106, 2010, pages 53 - 89
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
G. W. H. CHEESEMANE. S. G. WERSTIUK: "PrO—drugs as Novel Delivery Systems", vol. 14, 1985, ACS SYMPOSIUM SERIES, pages: 390 - 392
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
"Remington's Pharmaceutical Sciences", 1990
SUN LIANG-PENG, GAO LI-XIN, MA WEI-PING, NAN FA-JUN, LI JIA, PIAO HU-RI: "Synthesis and Biological Evaluation of 2,4,6-Trihydroxychalcone Derivatives as Novel Protein Tyrosine Phosphatase 1B Inhibitors : ", CHEMICAL BIOLOGY & DRUG DESIGN, BLACKWELL MUNKSGAARD, vol. 80, no. 4, 1 October 2012 (2012-10-01), pages 584 - 590, XP093031470, ISSN: 1747-0277, DOI: 10.1111/j.1747-0285.2012.01431.x
LIU, X. GO, M.L.: "Antiproliferative activity of chalcones with basic functionalities", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 15, no. 22, 26 September 2007 (2007-09-26), AMSTERDAM, NL, pages 7021 - 7034, XP022273627, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2007.07.042
LIU, X.L. TEE, H.W. GO, M.L.: "Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 16, no. 1, 1 January 2008 (2008-01-01), AMSTERDAM, NL, pages 171 - 180, XP022485938, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2007.10.006
K. S. GROSSMAN ET AL., ADV. CANCER RES, vol. 106, 2010, pages 53 - 89
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
G. W. H. CHEESEMANE. S. G. WERSTIUK: "PrO—drugs as Novel Delivery Systems", vol. 14, 1985, ACS SYMPOSIUM SERIES, pages: 390 - 392
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
"Remington's Pharmaceutical Sciences", 1990
Attorney, Agent or Firm:
FIWIS INTELLECTUAL PROPERTY LAW FIRM (CN)
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