Title:
SIGMA RECEPTOR LIGANDS AND THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO1993000313
Kind Code:
A3
Abstract:
The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment. The invention further relates to novel sigma receptor ligands having high binding to the sigma receptor and pharmaceutical compositions thereof. Unexpectedly, certain of the sigma receptor ligands of the present invention have selectivity for the sigma receptor over the DA, PCP and 5-HT1A receptors.
Inventors:
GLENNON RICHARD A (US)
Application Number:
PCT/US1992/005330
Publication Date:
March 04, 1993
Filing Date:
June 26, 1992
Export Citation:
Assignee:
UNIV VIRGINIA COMMONWEALTH (US)
International Classes:
A61K31/135; A61K31/17; A61K31/215; A61K31/275; A61K31/395; A61K31/40; A61K31/435; A61K31/44; A61K31/445; A61K31/4465; A61K31/451; A61K31/495; A61K31/505; A61K31/535; A61K31/5375; A61K31/55; A61P1/00; A61P9/12; A61P25/04; A61P25/06; A61P25/18; A61P25/24; A61P25/26; A61P25/30; A61P43/00; C07C211/08; C07C211/17; C07C211/27; C07C211/28; C07C211/29; C07C211/30; C07C211/42; C07C215/52; C07C217/16; C07C217/48; C07C217/60; C07C219/10; C07C219/12; C07C225/16; C07C229/46; C07C237/06; C07C243/18; C07C255/30; C07C255/58; C07C311/30; C07C317/26; C07C323/23; C07D207/12; C07D209/48; C07D211/14; C07D211/46; C07D211/48; C07D211/52; C07D211/70; C07D223/16; C07D239/42; C07D241/06; C07D265/30; C07D295/02; C07D295/03; C07D295/033; C07D295/06; C07D295/073; C07D295/096; C07D295/108; C07D295/192; C07D317/58; C07D451/02; C07D471/08; (IPC1-7): C07C/
Other References:
CHEMICAL ABSTRACTS, 66:46195h, 1967, BOISSIEN J.R. et al.
CHEMICAL ABSTRACTS, 69:51816C, 1968, OSBOND J.M. et al.
CAN. J. MICROBIOL., 26, 1980, COULTS R.T. et al., pages 844-849.
J. ORG. CHEM., 40(11), 1975, SMITH H.E. et al., pages 1562-1567.
CHEMICAL ABSTRACTS, 61:14559g, 1964, FREIFELDER M. et al.
See also references of EP 0591426A4
CHEMICAL ABSTRACTS, 69:51816C, 1968, OSBOND J.M. et al.
CAN. J. MICROBIOL., 26, 1980, COULTS R.T. et al., pages 844-849.
J. ORG. CHEM., 40(11), 1975, SMITH H.E. et al., pages 1562-1567.
CHEMICAL ABSTRACTS, 61:14559g, 1964, FREIFELDER M. et al.
See also references of EP 0591426A4
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