Title:
SILICONE MATERIAL, SILICONE TUBE, IMPLANT, PHARMACEUTICAL COMPOSITION, AND TEST METHOD FOR AMOUNT OF DRUG RELEASED
Document Type and Number:
WIPO Patent Application WO/2023/174450
Kind Code:
A2
Abstract:
Disclosed are a silicone material, a silicone tube, an implant, a pharmaceutical composition, and a test method for the amount of a drug released. a raw material composition of the silicone material comprises the following components in parts by weight: 100 parts of R-vinyl silicone rubber; 20-80 parts of a reinforcing agent; 0.3-3.0 parts of hydrogen-containing silicone oil; and ≥ 0.000002 parts of a catalyst, preferably being 0.000002-0.00005 parts; the content of vinyl groups in the R-vinyl silicone rubber is 0.10-0.50 mol%; the content of Si-H groups in the hydrogen-containing silicone oil is 0.18-1.6 mol%; the molar ratio of the Si-H groups in the hydrogen-containing silicone oil to the vinyl groups in the R-vinyl silicone rubber is (0.5-4):1; and optionally, said material further comprises an inhibitor. A silicone tube prepared by the silicone material has an excellent mechanical property and good biocompatibility; and an implant made from the silicone tube, upon loading with an active drug, has a stable drug release curve.
More Like This:
Inventors:
YANG XINGGANG (CN)
PI LINLING (CN)
YU HONG (CN)
SHEN RUI (CN)
SUN YUANHANG (CN)
PI LINLING (CN)
YU HONG (CN)
SHEN RUI (CN)
SUN YUANHANG (CN)
Application Number:
PCT/CN2023/094865
Publication Date:
September 21, 2023
Filing Date:
May 17, 2023
Export Citation:
Assignee:
SHENYANG XINGHUA PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C08L83/07
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
Download PDF:
Previous Patent: METHOD FOR PREPARING N-(3-CHLORO-4-(2-PYRIDYLMETHOXY)PHENYL)-2-CYANOACETAMIDE
Next Patent: CARBON DIOXIDE CAPTURE METHOD
Next Patent: CARBON DIOXIDE CAPTURE METHOD