Title:
SINGLE-CHAIN POLYPEPTIDES
Document Type and Number:
WIPO Patent Application WO/2021/142476
Kind Code:
A1
Abstract:
The present invention provides single-chain immunoregulatory polypeptides. These single-chain polypeptides have increased stability, reduced in vivo clearance, increased in
vivo half-life when used as a therapeutic, and enhanced potency in activating immune cells.
Inventors:
GRINBERG ASYA (US)
HEIN PYAE (US)
JUO ZONG (TW)
HEIN PYAE (US)
JUO ZONG (TW)
Application Number:
PCT/US2021/013091
Publication Date:
July 15, 2021
Filing Date:
January 12, 2021
Export Citation:
Assignee:
DRAGONFLY THERAPEUTICS INC (US)
International Classes:
A61P31/12; A61K38/20; A61P35/00; C07K14/54; C07K14/715; C07K16/18
Domestic Patent References:
| WO2019213517A1 | 2019-11-07 | |||
| WO2019204592A1 | 2019-10-24 | |||
| WO2012040323A2 | 2012-03-29 |
Foreign References:
| US8415456B2 | 2013-04-09 | |||
| US9493533B2 | 2016-11-15 | |||
| US8507222B2 | 2013-08-13 |
Other References:
HUANG HAOMIN ET AL: "A novel strategy to produce high level and high purity of bioactive IL15 fusion proteins from mammalian cells", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, vol. 148, 26 March 2018 (2018-03-26), pages 30 - 39, XP085392323, ISSN: 1046-5928, DOI: 10.1016/J.PEP.2018.03.010
VAN DEN BERGH JOHAN MJ ET AL: "IL-15 receptor alpha as the magic wand to boost the success of IL-15 antitumor therapies: The upswing of IL-15 transpresentation", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 170, 21 October 2016 (2016-10-21), pages 73 - 79, XP029895045, ISSN: 0163-7258, DOI: 10.1016/J.PHARMTHERA.2016.10.012
GUO YIN ET AL: "Immunobiology of the IL-15/IL-15R[alpha] complex as an antitumor and antiviral agent", CYTOKINE & GROWTH FACTOR REVIEWS, vol. 38, 1 September 2017 (2017-09-01), pages 10 - 21, XP085253997, ISSN: 1359-6101, DOI: 10.1016/J.CYTOGFR.2017.08.002
MARTIN: "Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
"GenBank", Database accession no. NP_002180.1
BOUCHAUD ET AL., J. MOL. BIOL., vol. 382, 2008, pages 1 - 12
LANGER, SCIENCE, vol. 249, 1990, pages 1527 - 1533
FIEDLER: "Lexikon der Hifsstoffe", 1996, EDITIO CANTOR VERLAG AULENDORF
STEIMER ET AL., CLINICA CHIMICA ACTA, vol. 308, 2001, pages 33 - 41
VAN DEN BERGH JOHAN MJ ET AL: "IL-15 receptor alpha as the magic wand to boost the success of IL-15 antitumor therapies: The upswing of IL-15 transpresentation", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 170, 21 October 2016 (2016-10-21), pages 73 - 79, XP029895045, ISSN: 0163-7258, DOI: 10.1016/J.PHARMTHERA.2016.10.012
GUO YIN ET AL: "Immunobiology of the IL-15/IL-15R[alpha] complex as an antitumor and antiviral agent", CYTOKINE & GROWTH FACTOR REVIEWS, vol. 38, 1 September 2017 (2017-09-01), pages 10 - 21, XP085253997, ISSN: 1359-6101, DOI: 10.1016/J.CYTOGFR.2017.08.002
MARTIN: "Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
"GenBank", Database accession no. NP_002180.1
BOUCHAUD ET AL., J. MOL. BIOL., vol. 382, 2008, pages 1 - 12
LANGER, SCIENCE, vol. 249, 1990, pages 1527 - 1533
FIEDLER: "Lexikon der Hifsstoffe", 1996, EDITIO CANTOR VERLAG AULENDORF
STEIMER ET AL., CLINICA CHIMICA ACTA, vol. 308, 2001, pages 33 - 41
Attorney, Agent or Firm:
ASHRAF, Shovon et al. (US)
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