Title:
SINGLE DOSE AZITHROMYCIN FOR TREATING RESPIRATORY INFECTIONS
Document Type and Number:
WIPO Patent Application WO2003018031
Kind Code:
A3
Abstract:
The present invention relates to a method of treating respiratory infections in humans by administering a single dose of azithromycin.
Inventors:
DUNNE MICHAEL WILLIAM (US)
Application Number:
PCT/IB2002/003076
Publication Date:
October 02, 2003
Filing Date:
July 31, 2002
Export Citation:
Assignee:
PFIZER PROD INC (US)
DUNNE MICHAEL WILLIAM (US)
DUNNE MICHAEL WILLIAM (US)
International Classes:
A61K31/7052; A61P11/00; C07H17/00; A61P27/16; A61P31/04; A61K; A61P; (IPC1-7): A61K31/7052; A61P11/00; A61P31/04; A61P27/16
Other References:
SCHÖNWALD S ET AL: "Azithromycin: single 1.5 g dose in the treatment of patients with atypical pneumonia syndrome--a randomized study.", INFECTION. GERMANY 1999 MAY-JUN, vol. 27, no. 3, May 1999 (1999-05-01), pages 198 - 202, XP008018295, ISSN: 0300-8126
AMSDEN G W ET AL: "Serum and WBC pharmacokinetics of 1500 mg of azithromycin when given either as a single dose or over a 3 day period in healthy volunteers.", THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. ENGLAND JAN 2001, vol. 47, no. 1, January 2001 (2001-01-01), pages 61 - 66, XP001159703, ISSN: 0305-7453
BLOCK STAN L ET AL: "Single dose azithromycin (30 mg/kg) in acute otitis media.", CLINICAL INFECTIOUS DISEASES, vol. 31, no. 1, July 2000 (2000-07-01), 2000 Annual Meeting of the Infectious Diseases Society of America;New Orleans, Louisiana, USA; September 07-10, 2000, pages 243, XP008018309, ISSN: 1058-4838
MÜLLER O: "Comparison of azithromycin versus clarithromycin in the treatment of patients with upper respiratory tract infections.", THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. ENGLAND JUN 1993, vol. 31 Suppl E, June 1993 (1993-06-01), pages 137 - 146, XP008018300, ISSN: 0305-7453
NIGHTINGALE C H ET AL: "Comparative bactericidal activity of clarithromycin, azithromycin, and cefuroxime against Streptococcus pneumoniae", JOURNAL OF INFECTIOUS DISEASE PHARMACOTHERAPY 1999 UNITED STATES, vol. 4, no. 1, 1999, pages 17 - 24, XP008018297, ISSN: 1068-7777
AOKI N: "Pharmacokinetics of azithromycin and its clinical results", JAPANESE JOURNAL OF CHEMOTHERAPY 1995 JAPAN, vol. 43, no. SUPPL. 6, 1995, pages 234 - 238, XP008018296, ISSN: 1340-7007
MORRIS D L ET AL: "High and prolonged pulmonary tissue concentrations of azithromycin following a single oral dose.", EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES: OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF CLINICAL MICROBIOLOGY. GERMANY OCT 1991, vol. 10, no. 10, October 1991 (1991-10-01), pages 859 - 861, XP008018299, ISSN: 0934-9723
KLEPSER M ET AL: "Efficacy of clarithromycin (CL) and azithromycin (AZ) against Streptococcus pneumoniae (SPN) with various macrolide resistance mechanisms in a neutropenic murine respiratory infection model.", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, vol. 17, no. Supplement 1, June 2001 (2001-06-01), 22nd International Congress of Chemotherapy;Amsterdam, Netherlands; June 30-July 03, 2001, pages S157, XP002244592, ISSN: 0924-8579
BERGOGNE-BEREZIN EUGENIE: "Azithromycin: Tissue pharmacokinetic data.", PATHOLOGIE BIOLOGIE, vol. 43, no. 6, 1995, pages 498 - 504, XP008018308, ISSN: 0369-8114
JORGENSEN DANIEL M ET AL: "Single dose azithromycin is safe and effective in the treatment of acute otitis media.", PEDIATRIC RESEARCH, vol. 51, no. 4 Part 2, April 2002 (2002-04-01), Annual Meeting of the Pediatric Societies';Baltimore, MD, USA; May 04-07, 2002, April, 2002, pages 284A, XP008018310, ISSN: 0031-3998
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2002, GIRARD D ET AL: "Accelerated dosing of azithromcyin in preclinical infection models.", XP002244593, Database accession no. PREV200200584685
AMSDEN G W ET AL: "Serum and WBC pharmacokinetics of 1500 mg of azithromycin when given either as a single dose or over a 3 day period in healthy volunteers.", THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. ENGLAND JAN 2001, vol. 47, no. 1, January 2001 (2001-01-01), pages 61 - 66, XP001159703, ISSN: 0305-7453
BLOCK STAN L ET AL: "Single dose azithromycin (30 mg/kg) in acute otitis media.", CLINICAL INFECTIOUS DISEASES, vol. 31, no. 1, July 2000 (2000-07-01), 2000 Annual Meeting of the Infectious Diseases Society of America;New Orleans, Louisiana, USA; September 07-10, 2000, pages 243, XP008018309, ISSN: 1058-4838
MÜLLER O: "Comparison of azithromycin versus clarithromycin in the treatment of patients with upper respiratory tract infections.", THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. ENGLAND JUN 1993, vol. 31 Suppl E, June 1993 (1993-06-01), pages 137 - 146, XP008018300, ISSN: 0305-7453
NIGHTINGALE C H ET AL: "Comparative bactericidal activity of clarithromycin, azithromycin, and cefuroxime against Streptococcus pneumoniae", JOURNAL OF INFECTIOUS DISEASE PHARMACOTHERAPY 1999 UNITED STATES, vol. 4, no. 1, 1999, pages 17 - 24, XP008018297, ISSN: 1068-7777
AOKI N: "Pharmacokinetics of azithromycin and its clinical results", JAPANESE JOURNAL OF CHEMOTHERAPY 1995 JAPAN, vol. 43, no. SUPPL. 6, 1995, pages 234 - 238, XP008018296, ISSN: 1340-7007
MORRIS D L ET AL: "High and prolonged pulmonary tissue concentrations of azithromycin following a single oral dose.", EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES: OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF CLINICAL MICROBIOLOGY. GERMANY OCT 1991, vol. 10, no. 10, October 1991 (1991-10-01), pages 859 - 861, XP008018299, ISSN: 0934-9723
KLEPSER M ET AL: "Efficacy of clarithromycin (CL) and azithromycin (AZ) against Streptococcus pneumoniae (SPN) with various macrolide resistance mechanisms in a neutropenic murine respiratory infection model.", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, vol. 17, no. Supplement 1, June 2001 (2001-06-01), 22nd International Congress of Chemotherapy;Amsterdam, Netherlands; June 30-July 03, 2001, pages S157, XP002244592, ISSN: 0924-8579
BERGOGNE-BEREZIN EUGENIE: "Azithromycin: Tissue pharmacokinetic data.", PATHOLOGIE BIOLOGIE, vol. 43, no. 6, 1995, pages 498 - 504, XP008018308, ISSN: 0369-8114
JORGENSEN DANIEL M ET AL: "Single dose azithromycin is safe and effective in the treatment of acute otitis media.", PEDIATRIC RESEARCH, vol. 51, no. 4 Part 2, April 2002 (2002-04-01), Annual Meeting of the Pediatric Societies';Baltimore, MD, USA; May 04-07, 2002, April, 2002, pages 284A, XP008018310, ISSN: 0031-3998
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2002, GIRARD D ET AL: "Accelerated dosing of azithromcyin in preclinical infection models.", XP002244593, Database accession no. PREV200200584685
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