Title:
SINGLE-STRAND FORM POLYNUCLEOTIDE AND USE THEREOF IN GENOME EDITING
Document Type and Number:
WIPO Patent Application WO/2023/190848
Kind Code:
A1
Abstract:
The present invention provides: a single-strand form polynucleotide for editing that is capable of modifying a target site in double-strand genomic DNA and that includes, as a structural unit, a nucleotide analog with a high affinity for DNA; a genome editing kit that includes said polynucleotide for editing; a genome editing kit that includes said polynucleotide for editing and a polynucleotide for promoting editing or an expression vector thereof; a method for modifying a target site in double-strand genomic DNA of a cell or a non-human organism, the method comprising a step for using the genome editing kit to treat a cell or an organism; and a method for producing a cell or an organism in which a target site in double-strand genomic DNA is modified, the method comprising said step.
Inventors:
MASEDA HIDEAKI (JP)
Application Number:
PCT/JP2023/013138
Publication Date:
October 05, 2023
Filing Date:
March 30, 2023
Export Citation:
Assignee:
AIST (JP)
International Classes:
C12N15/09; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/11
Domestic Patent References:
| WO2018097257A1 | 2018-05-31 | |||
| WO2018030536A1 | 2018-02-15 | |||
| WO2019036612A1 | 2019-02-21 |
Foreign References:
| JP2018506297A | 2018-03-08 | |||
| US20140275207A1 | 2014-09-18 |
Other References:
BRAASCH D A, COREY D R: "Novel antisense and peptide nucleic strategies for controlling gene expression", BIOCHEMISTRY, vol. 41, no. 14, 9 April 2002 (2002-04-09), pages 4503 - 4510, XP002975681, ISSN: 0006-2960, DOI: 10.1021/bi0122112
Attorney, Agent or Firm:
IP-ASSIST PATENT PARTNERS (JP)
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