Title:
SINGLE-STRANDED OLIGONUCLEOTIDES FOR USE IN THE MEDICAL TREATMENT AND/OR PROPHYLAXIS OF VIRUS INFECTIONS
Document Type and Number:
WIPO Patent Application WO/2022/229350
Kind Code:
A3
Abstract:
The present disclosure relates to non-CpG single-stranded oligonucleotides (ssONs) with broad-spectrum antiviral activity for use in the treatment and/or prophylaxis of viral infections, such as Herpes simplex virus, Ebola virus, Lassa virus, Lyssa virus, rabies virus, measles virus, vesicular stomatitis virus (VSV), murine leukemia virus (MLV) and HIV-1, as well as multi-resistant HIV-1 infections, in a subject. Said ssONs have a length of at least 25 nucleotides and are stabilized by phosphorothioate internucleotide linkages and/or 2'-O-Methyl modifications.
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Inventors:
SPETZ ANNA-LENA (SE)
Application Number:
PCT/EP2022/061404
Publication Date:
December 08, 2022
Filing Date:
April 28, 2022
Export Citation:
Assignee:
TIRMED PHARMA AB (SE)
International Classes:
C12N15/11; A61K31/7125
Domestic Patent References:
| WO2019048555A1 | 2019-03-14 | |||
| WO2016202779A1 | 2016-12-22 |
Other References:
CARDIN RHONDA D ET AL: "Amphipathic DNA polymers exhibit antiviral activity against systemic Murine Cytomegalovirus infection", VIROLOGY JOURNAL, BIOMED CENTRAL, LONDON, GB, vol. 6, no. 1, 2 December 2009 (2009-12-02), pages 214, XP021069018, ISSN: 1743-422X
D. I. BERNSTEIN ET AL: "Amphipathic DNA Polymers Exhibit Antiherpetic Activity In Vitro and In Vivo", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 52, no. 8, 1 August 2008 (2008-08-01), US, pages 2727 - 2733, XP055641550, ISSN: 0066-4804, DOI: 10.1128/AAC.00279-08
ANDREW VAILLANT ET AL: "Phosphorothioate Oligonucleotides Inhibit Human Immunodeficiency Virus Type 1 Fusion by Blocking gp41 Core Formation", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 50, no. 4, 1 April 2006 (2006-04-01), US, pages 1393 - 1401, XP055705135, ISSN: 0066-4804, DOI: 10.1128/AAC.50.4.1393-1401.2006
NOWROOZALIZADEH SALMA ET AL: "Suppression of HIV replication in vitro by CpG and CpG conjugated to the non toxic B subunit of cholera toxin", CURRENT HIV RESEARCH,, vol. 6, no. 3, 30 April 2008 (2008-04-30), pages 230 - 238, XP009538194, ISSN: 1873-4251, DOI: 10.2174/157016208784325038
CARSTEN SCHELLER ET AL: "Dual Activity of Phosphorothioate CpG Oligodeoxynucleotides on HIV", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, US, vol. 1091, no. 1, 26 January 2007 (2007-01-26), pages 540 - 547, XP071403659, ISSN: 0077-8923, DOI: 10.1196/ANNALS.1378.095
D. I. BERNSTEIN ET AL: "Amphipathic DNA Polymers Exhibit Antiherpetic Activity In Vitro and In Vivo", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 52, no. 8, 1 August 2008 (2008-08-01), US, pages 2727 - 2733, XP055641550, ISSN: 0066-4804, DOI: 10.1128/AAC.00279-08
ANDREW VAILLANT ET AL: "Phosphorothioate Oligonucleotides Inhibit Human Immunodeficiency Virus Type 1 Fusion by Blocking gp41 Core Formation", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 50, no. 4, 1 April 2006 (2006-04-01), US, pages 1393 - 1401, XP055705135, ISSN: 0066-4804, DOI: 10.1128/AAC.50.4.1393-1401.2006
NOWROOZALIZADEH SALMA ET AL: "Suppression of HIV replication in vitro by CpG and CpG conjugated to the non toxic B subunit of cholera toxin", CURRENT HIV RESEARCH,, vol. 6, no. 3, 30 April 2008 (2008-04-30), pages 230 - 238, XP009538194, ISSN: 1873-4251, DOI: 10.2174/157016208784325038
CARSTEN SCHELLER ET AL: "Dual Activity of Phosphorothioate CpG Oligodeoxynucleotides on HIV", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, US, vol. 1091, no. 1, 26 January 2007 (2007-01-26), pages 540 - 547, XP071403659, ISSN: 0077-8923, DOI: 10.1196/ANNALS.1378.095
Attorney, Agent or Firm:
AWA SWEDEN AB (SE)
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